Table 1. Kinetic model parameters... | Rockefeller University Press

Table 1.

Kinetic model parameters

Transition	Symbol	WT (n = 6)		ΔCNBHD (n = 6)
Transition	Symbol	k₀	q	k₀	q
		s⁻¹	e⁻	s⁻¹	e⁻
C0 → C1	α	16.3 ± 1.4	0.05	9.8 ± 1.5	0.05
C1 → C0	β	0.78 ± 0.22	−0.45	0.66 ± 0.31	−0.45
C1 → C2	γ	270 ± 135	0.60	18.8 ± 7.4	0.60
C2 → C1	δ	0.47 ± 0.3	−1.4	1.38 ± 0.4	−1.4
C2 → O	o	145 ± 70.1	NA	145	NA
O → C2	c	170 ± 52	−0.50	2,066 ± 47	−0.50
O → I	i	91 ± 49.2	0.39 ± 0.13	91	0.39
I → O	r	619 ± 402	−0.50	619	−0.50

Transition	Symbol	WT (n = 6)		ΔCNBHD (n = 6)
Transition	Symbol	k₀	q	k₀	q
		s⁻¹	e⁻	s⁻¹	e⁻
C0 → C1	α	16.3 ± 1.4	0.05	9.8 ± 1.5	0.05
C1 → C0	β	0.78 ± 0.22	−0.45	0.66 ± 0.31	−0.45
C1 → C2	γ	270 ± 135	0.60	18.8 ± 7.4	0.60
C2 → C1	δ	0.47 ± 0.3	−1.4	1.38 ± 0.4	−1.4
C2 → O	o	145 ± 70.1	NA	145	NA
O → C2	c	170 ± 52	−0.50	2,066 ± 47	−0.50
O → I	i	91 ± 49.2	0.39 ± 0.13	91	0.39
I → O	r	619 ± 402	−0.50	619	−0.50

NA, not applicable. Voltage-dependent rate constants are given by k(V) = k₀ exp(qV/k_BT), where k₀ is the voltage-independent rate, q is the effective charge moved from the initial state up to the transition state intermediate, V is voltage, k_B is Boltzmann’s constant, and T is temperature (held at 298.15 K). Parameters are the mean ± SEM for models optimized to data from individual oocytes.

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