Table 1.
Effect of the α2δ-1 subunit on CaV1.2 (α1C/β3) VSD activation kinetics (100-ms depolarizations to 20 mV)
VSDParameterNo α2δWith α2δ-1
VSD I τ1 (ms) 5.48 ± 1.57 (n = 4) 3.8 ± 0.37 (n = 3) 
 α1 (%) 47.2 ± 3.7 63.9 ± 7.7 
 τ2 (ms) 56.3 ± 7.9 29.6 ± 6.0 
 τavg (ms) 31.4 ± 2.3 13.6 ± 3.7 
VSD II τ1 (ms) 0.83 ± 0.32 (n = 3) 1.04 ± 0.39 (n = 3) 
 α1 (%) 43.1 ± 2.0 66.2 ± 8.6 
 τ2 (ms) 28.3 ± 12.5 30.7 ± 5.7 
 τavg (ms) 16.5 ± 7.2 11.9 ± 3.6 
VSD III τ1 (ms) 2.39 ± 0.44 (n = 6) 2.0 ± 0.17 (n = 4) 
 α1 (%) 91.8 ± 5.5 83.5 ± 9.7 
 τ2 (ms) 37.9 ± 7.9 32.0 ± 9.0 
 τavg (ms) 4.6 ± 1.1 5.09 ± 0.98 
VSD IV τ1 (ms) 21.5 ± 1.9 (n = 6) 16.5 ± 2.1 (n = 3) 
 α1 (%) 100 100 
 τ2 (ms) NA NA 
 τavg (ms) 21.5 ± 1.9 16.5 ± 2.1 
VSDParameterNo α2δWith α2δ-1
VSD I τ1 (ms) 5.48 ± 1.57 (n = 4) 3.8 ± 0.37 (n = 3) 
 α1 (%) 47.2 ± 3.7 63.9 ± 7.7 
 τ2 (ms) 56.3 ± 7.9 29.6 ± 6.0 
 τavg (ms) 31.4 ± 2.3 13.6 ± 3.7 
VSD II τ1 (ms) 0.83 ± 0.32 (n = 3) 1.04 ± 0.39 (n = 3) 
 α1 (%) 43.1 ± 2.0 66.2 ± 8.6 
 τ2 (ms) 28.3 ± 12.5 30.7 ± 5.7 
 τavg (ms) 16.5 ± 7.2 11.9 ± 3.6 
VSD III τ1 (ms) 2.39 ± 0.44 (n = 6) 2.0 ± 0.17 (n = 4) 
 α1 (%) 91.8 ± 5.5 83.5 ± 9.7 
 τ2 (ms) 37.9 ± 7.9 32.0 ± 9.0 
 τavg (ms) 4.6 ± 1.1 5.09 ± 0.98 
VSD IV τ1 (ms) 21.5 ± 1.9 (n = 6) 16.5 ± 2.1 (n = 3) 
 α1 (%) 100 100 
 τ2 (ms) NA NA 
 τavg (ms) 21.5 ± 1.9 16.5 ± 2.1 

NA, not applicable.

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