Table 2.
Single-channel conductance in selected K+ channels
Accession no.GeneProteinPore helix-S6 sequencepSReference
Pore helixSelectivity filterPore-S6
Small conductance            
NP_728123.1 SHAKER Shaker  AFWWAVVTMT TVGYGD MTPVGVWGKIVGSLCAIAGVLTIALPV P VIVSNFNYFYHR  487 20  Carvacho et al., 2008  
NP_000208.2 KCNA1 Kv1.1  AFWWAVVSMT TVGYGD MYPVTIGGKIVGSLCAIAGVLTIALPV P VIVSNFNYFYHR  417 10  Gutman et al., 2005  
NP_004965.1 KCNA2 Kv1.2  AFWWAVVSMT TVGYGD MVPTTIGGKIVGSLCAIAGVLTIALPV P VIVSNFNYFYHR  419 14  Carvacho et al., 2008  
AAC31761.1 KCNA3 Kv1.3  AFWWAVVTMT TVGYGD MHPVTIGGKIVGSLCAIAGVLTIALPV P VIVSNFNYFYHR  737 13  Gutman et al., 2005  
NP_002224.1 KCNA4 Kv1.4  AFWWAVVTMT TVGYGD MKPITVGGKIVGSLCAIAGVLTIALPV P VIVSNFNYFYHR  569 5  Gutman et al., 2005  
AAA61276.1 KCNA5 Kv1.5  AFWWAVVTMT TVGYGD MRPITVGGKIVGSLCAIAGVLTIALPV P VIVSNFNYFYHR  523 10  Carvacho et al., 2008  
NP_002226.1 KCNA6 Kv1.6  AFWWAVVTMT TVGYGD MYPMTVGGKIVGSLCAIAGVLTIALPV P VIVSNFNYFYHR  467 9  Gutman et al., 2005  
AAX11186.1 KCNA7 Kv1.7  SFWWAVVTMT TVGYGD MAPVTVGGKIVGSLCAIAGVLTISLPV P VIVSNFSYFYHR  403 21  Carvacho et al., 2008  
NP_005540.1 KCA10 Kv1.8  GFWWAVVTMT TVGYGD MCPTTPGGKIVGTLCAIAGVLTIALPV P VIVSNFNYFYHR  466 12  Gutman et al., 2005  
NP_004761.2 KCNB2 Kv2.2  SFWWATITMT TVGYGD IYPKTLLGKIVGGLCCIAGVLVIALPI P IIVNNFSEFYKE  426 15  Carvacho et al., 2008  
Large conductance            
P0A334.1 KCSA KcsA  ALWWSVETAT TVGYGD LYPVTLWGRLVAVVVMVAGITSFGLVT A ALATWFVGREQE  120 100  Nimigean et al., 2003  
Q9YDF8.1 KVAP KvAP  ALWWAVVTAT TVGYGD VVPATPIGKVIGIAVMLTGISALTLLI G TVSNMFQKILVG  253 170  Ruta et al., 2003  
O27564.1 MTHK MthK  SLYWTFVTIA TVGYGD YSPSTPLGMYFTVTLIVLGIGTFAVAV E RLLEFLINREQM  104 200  Shi et al., 2011  
NP_001240307.1 KCMA1 MSlo1  CVYLLMVTMS TVGYGD VYAKTTLGRLFMVFFILGGLAMFASYV P EIIELIGNRKKY  332 270  Brelidze et al., 2003  
Accession no.GeneProteinPore helix-S6 sequencepSReference
Pore helixSelectivity filterPore-S6
Small conductance            
NP_728123.1 SHAKER Shaker  AFWWAVVTMT TVGYGD MTPVGVWGKIVGSLCAIAGVLTIALPV P VIVSNFNYFYHR  487 20  Carvacho et al., 2008  
NP_000208.2 KCNA1 Kv1.1  AFWWAVVSMT TVGYGD MYPVTIGGKIVGSLCAIAGVLTIALPV P VIVSNFNYFYHR  417 10  Gutman et al., 2005  
NP_004965.1 KCNA2 Kv1.2  AFWWAVVSMT TVGYGD MVPTTIGGKIVGSLCAIAGVLTIALPV P VIVSNFNYFYHR  419 14  Carvacho et al., 2008  
AAC31761.1 KCNA3 Kv1.3  AFWWAVVTMT TVGYGD MHPVTIGGKIVGSLCAIAGVLTIALPV P VIVSNFNYFYHR  737 13  Gutman et al., 2005  
NP_002224.1 KCNA4 Kv1.4  AFWWAVVTMT TVGYGD MKPITVGGKIVGSLCAIAGVLTIALPV P VIVSNFNYFYHR  569 5  Gutman et al., 2005  
AAA61276.1 KCNA5 Kv1.5  AFWWAVVTMT TVGYGD MRPITVGGKIVGSLCAIAGVLTIALPV P VIVSNFNYFYHR  523 10  Carvacho et al., 2008  
NP_002226.1 KCNA6 Kv1.6  AFWWAVVTMT TVGYGD MYPMTVGGKIVGSLCAIAGVLTIALPV P VIVSNFNYFYHR  467 9  Gutman et al., 2005  
AAX11186.1 KCNA7 Kv1.7  SFWWAVVTMT TVGYGD MAPVTVGGKIVGSLCAIAGVLTISLPV P VIVSNFSYFYHR  403 21  Carvacho et al., 2008  
NP_005540.1 KCA10 Kv1.8  GFWWAVVTMT TVGYGD MCPTTPGGKIVGTLCAIAGVLTIALPV P VIVSNFNYFYHR  466 12  Gutman et al., 2005  
NP_004761.2 KCNB2 Kv2.2  SFWWATITMT TVGYGD IYPKTLLGKIVGGLCCIAGVLVIALPI P IIVNNFSEFYKE  426 15  Carvacho et al., 2008  
Large conductance            
P0A334.1 KCSA KcsA  ALWWSVETAT TVGYGD LYPVTLWGRLVAVVVMVAGITSFGLVT A ALATWFVGREQE  120 100  Nimigean et al., 2003  
Q9YDF8.1 KVAP KvAP  ALWWAVVTAT TVGYGD VVPATPIGKVIGIAVMLTGISALTLLI G TVSNMFQKILVG  253 170  Ruta et al., 2003  
O27564.1 MTHK MthK  SLYWTFVTIA TVGYGD YSPSTPLGMYFTVTLIVLGIGTFAVAV E RLLEFLINREQM  104 200  Shi et al., 2011  
NP_001240307.1 KCMA1 MSlo1  CVYLLMVTMS TVGYGD VYAKTTLGRLFMVFFILGGLAMFASYV P EIIELIGNRKKY  332 270  Brelidze et al., 2003  

Multiple alignment of the primary structure of K+ channel pores. The signature sequence TVGYGD on the selectivity filter, used as reference for the alignments, is separated for clarity. Shaker’s Gly466 and aligning residues are underlined. Shaker’s 475 and aligning residues in Kv channels are individualized for clarity. Aligning with Shaker 475 are KcsA’s Ala108, KvAP’s Gly241, MthK’s Glu92 and MSlo1’s Pro320. Aspartates and glutamates are in bold (table modified from Moscoso et al. [2012] with permission from Elsevier).

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