Table 1.
Summary of current inhibition by Cd2+ on mutants carrying cross-linkable cysteine pairs
Cysteine pairs% Inhibition
TM1/TM6  
102C/341C 95.6 ± 3 
106C/337C 90.7 ± 4 
107C/337C 105.6 ± 5.5 
107C/338C 98.6 ± 3.8 
TM6/TM12  
348C/1141C 88.6 ± 2.7 
348C/1144C 80.3 ± 3.7 
348C/1145C 77.2 ± 3.1 
TM1/TM12  
95C/1141C 92.9 ± 2.1 
Cysteine pairs% Inhibition
TM1/TM6  
102C/341C 95.6 ± 3 
106C/337C 90.7 ± 4 
107C/337C 105.6 ± 5.5 
107C/338C 98.6 ± 3.8 
TM6/TM12  
348C/1141C 88.6 ± 2.7 
348C/1144C 80.3 ± 3.7 
348C/1145C 77.2 ± 3.1 
TM1/TM12  
95C/1141C 92.9 ± 2.1 

Note that the >100% inhibition with 107C/337C results from the observations in some experiments where the current level in the presence of Cd2+ is even lower than that at the beginning of the recording or under CFTR Inh-172.

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