Table 1. Voltage of half-maximal... | Rockefeller University Press

Table 1.

Voltage of half-maximal activation (V_1/2) and current density at maximal activation (I_peak)

Constructs	V_1/2 (mV)				I_peak (pA/pF)				N
	Mean	SD	SEM	P	Mean	SD	SEM	P
Ca_V1.1a	34.8	4.9	0.9	na,^†††	1.8	0.7	0.1	na,^†††	31
Ca_V1.1e	6.7	5.7	1.0	***,na	10.5	4.3	0.7	***,na	30
Ca_V1.1a-L_1212/1215N	23.0	5.1	1.5	***,^†††	4.8	2.4	0.7	ns,ns	12
Ca_V1.1e-L_I	11.7	4.5	0.9	***,^†	12.5	6.6	1.3	***,ns	25
Ca_V1.1e-L4_I	36.4	8.3	3.1	ns,^†††	0.6	0.2	0.1	ns,^†††	7
Ca_V1.1e-3L_I	12.4	3.8	1.4	***,ns	5.8	2.3	0.8	ns,ns	7
Ca_V1.1a-CS_I	31.3	4.0	1.1	ns,^†††	2.3	1.8	0.5	ns,^†††	12
Ca_V1.1e-CS_I	−1.6	6.4	2.1	***,^††	12.0	8.3	2.7	***,ns	9
Ca_V1.1e-L_I-3L_IV	36.1	5.7	1.5	ns,^†††	2.1	1.2	0.3	ns,^†††	14
Ca_V1.1e-L_I-L4_IV	5.2	3.3	0.9	***,ns	9.6	4.3	1.2	***,ns	12
Ca_V1.1e-L_I-L_IV	21.2	7.3	1.7	***,^†††	7.0	3.1	0.7	***,ns	18
Ca_V1.1e-L_I-3L4_IV	10.6	5.3	2.0	***,ns	8.7	4.5	1.7	**,ns	7

Constructs	V_1/2 (mV)				I_peak (pA/pF)				N
	Mean	SD	SEM	P	Mean	SD	SEM	P
Ca_V1.1a	34.8	4.9	0.9	na,^†††	1.8	0.7	0.1	na,^†††	31
Ca_V1.1e	6.7	5.7	1.0	***,na	10.5	4.3	0.7	***,na	30
Ca_V1.1a-L_1212/1215N	23.0	5.1	1.5	***,^†††	4.8	2.4	0.7	ns,ns	12
Ca_V1.1e-L_I	11.7	4.5	0.9	***,^†	12.5	6.6	1.3	***,ns	25
Ca_V1.1e-L4_I	36.4	8.3	3.1	ns,^†††	0.6	0.2	0.1	ns,^†††	7
Ca_V1.1e-3L_I	12.4	3.8	1.4	***,ns	5.8	2.3	0.8	ns,ns	7
Ca_V1.1a-CS_I	31.3	4.0	1.1	ns,^†††	2.3	1.8	0.5	ns,^†††	12
Ca_V1.1e-CS_I	−1.6	6.4	2.1	***,^††	12.0	8.3	2.7	***,ns	9
Ca_V1.1e-L_I-3L_IV	36.1	5.7	1.5	ns,^†††	2.1	1.2	0.3	ns,^†††	14
Ca_V1.1e-L_I-L4_IV	5.2	3.3	0.9	***,ns	9.6	4.3	1.2	***,ns	12
Ca_V1.1e-L_I-L_IV	21.2	7.3	1.7	***,^†††	7.0	3.1	0.7	***,ns	18
Ca_V1.1e-L_I-3L4_IV	10.6	5.3	2.0	***,ns	8.7	4.5	1.7	**,ns	7

Numerical values represent mean, SD, SEM, and number of samples (N). Statistical differences between mutants, chimeras, and Ca_V1.1a or Ca_V1.1e were determined with one-way ANOVA, followed by a Bonferroni multiple comparison test. Significant differences against Ca_V1.1a are indicated as **, P < 0.001; ***, P < 0.0001. Differences against Ca_V1.1e are indicated as ^†, P < 0.05; ^††, P < 0.001; ^†††, P < 0.0001. ns, not significant (P < 0.05); na, not applicable.

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