Table 1. Nominal and free antiarrhythmic... | Rockefeller University Press

Table 1.

Nominal and free antiarrhythmic concentrations

Antiarrhythmic	Clinical plasma concentrations (µM)			LogP^a	m_m^b
		Experimental concentrations (µM)
		Nominal	Free
Dronedarone	0.15–0.3^c	10	7 × 10⁻⁵	8.75	4.0 × 10⁻²
Amiodarone	1^d	30	1 × 10⁻³	7.8	10⁻¹
Propranolol	0.01–1^e	200	90	3.48	2.5 × 10⁻¹
Pindolol	0.04^f	300	300	1.75	1.5 × 10⁻²

Antiarrhythmic	Clinical plasma concentrations (µM)			LogPa	m_mb
		Experimental concentrations (µM)
		Nominal	Free
Dronedarone	0.15–0.3c	10	7 × 10⁻⁵	8.75	4.0 × 10⁻²
Amiodarone	1d	30	1 × 10⁻³	7.8	10⁻¹
Propranolol	0.01–1e	200	90	3.48	2.5 × 10⁻¹
Pindolol	0.04f	300	300	1.75	1.5 × 10⁻²

Benet et al. (2011).

Estimated following Bruno et al. (2007), Ingólfsson et al. (2007), and Rusinova et al. (2011).

Heijman et al. (2013a).

Haffajee et al. (1983), Latini et al. (1984), and Seydel (2003).

Woosley et al. (1979), Wilson et al. (1982), and Seydel (2003).

Channer et al. (1994) and Mehvar and Brocks (2001).

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