Table 1. Unitary channel properties for... | Rockefeller University Press

Table 1.

Unitary channel properties for WT CRAC, STIM1_1–469, and Orai1 W76A

Channel	P_o	i_Na	i_Ca	Ca²⁺ affinity (K_1/2)	n_H	n
		fA	fA	µM
WT CRAC^a	0.81 ± 0.02	79.6 ± 2.4	9.6 ± 0.4	24.2 ± 2.0	0.87 ± 0.10	3
STIM1_1–469^b	0.78 ± 0.02	79.9 ± 6.6	14.0 ± 1.5	32.0 ± 4.5	1.13 ± 0.11	4
Orai1 W76A^c	0.76 ± 0.04	83.4 ± 9.2	12.4 ± 2.3	26.4 ± 4.4	1.11 ± 0.08	3

Channel	P_o	i_Na	i_Ca	Ca²⁺ affinity (K_1/2)	n_H	n
		fA	fA	µM
WT CRAC^a	0.81 ± 0.02	79.6 ± 2.4	9.6 ± 0.4	24.2 ± 2.0	0.87 ± 0.10	3
STIM1_1–469^b	0.78 ± 0.02	79.9 ± 6.6	14.0 ± 1.5	32.0 ± 4.5	1.13 ± 0.11	4
Orai1 W76A^c	0.76 ± 0.04	83.4 ± 9.2	12.4 ± 2.3	26.4 ± 4.4	1.11 ± 0.08	3

All channel properties were measured at −100 mV.

WT STIM1 + WT Orai1; data reproduced from Mullins et al. (2016).

STIM1_1–469 + WT Orai1.

WT STIM1 + Orai1 W76A.