Unitary channel properties for WT Orai1, Y80K, and Y80E
| Orai1 channel | Po | iNa | iCa | Ca2+ affinity (K1/2) | nH | n |
| fA | fA | µM | ||||
| WT | 0.81 ± 0.02 | 79.6 ± 2.4 | 9.6 ± 0.4 | 24.2 ± 2.0 | 0.87 ± 0.10 | 3 |
| Y80K | 0.81 ± 0.02 | 91.5 ± 7.7 | 8.3 ± 1.1 | 33.5 ± 3.6 | 1.26 ± 0.10 | 4 |
| Y80E | 0.78 ± 0.02 | 147.6 ± 10.3 | 23.0 ± 4.4 | 63.5 ± 7.8 | 1.68 ± 0.20 | 4 |
| Orai1 channel | Po | iNa | iCa | Ca2+ affinity (K1/2) | nH | |
| WT | 0.81 ± 0.02 | 79.6 ± 2.4 | 9.6 ± 0.4 | 24.2 ± 2.0 | 0.87 ± 0.10 | 3 |
| Y80K | 0.81 ± 0.02 | 91.5 ± 7.7 | 8.3 ± 1.1 | 33.5 ± 3.6 | 1.26 ± 0.10 | 4 |
| Y80E | 0.78 ± 0.02 | 147.6 ± 10.3 | 23.0 ± 4.4 | 63.5 ± 7.8 | 1.68 ± 0.20 | 4 |
All channel properties were measured at –100 mV.
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