Table 1.

Permeability ratios (PK/PCl) of channels

Channel 100 mM KCl 250 mM KCl 
WT (PA63)7 22.2 9.1 
(PA63E302S)7 17.5 8.9 
(PA63E343S)7 20.8 8.7 
(PA63D276S)7 20.8 8.3 
(PA63D335S)7 15.4 8.2 
(PA63E308S)7 14.7 7.7 
(PA63D315S)7 12.2 6.5 
(PA63F427A)7 9.5 4.6 
Channel 100 mM KCl 250 mM KCl 
WT (PA63)7 22.2 9.1 
(PA63E302S)7 17.5 8.9 
(PA63E343S)7 20.8 8.7 
(PA63D276S)7 20.8 8.3 
(PA63D335S)7 15.4 8.2 
(PA63E308S)7 14.7 7.7 
(PA63D315S)7 12.2 6.5 
(PA63F427A)7 9.5 4.6 

Permeability ratios (PK/PCl) of channels, calculated by applying the GHK equation to the cation selectivity profiles of each channel with [KCl]trans = 100 and 250 mM KCl. Numbers represent PK/PCl.

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