Effect of mutations at position 9′ of the M2 α-helix on the time course of deactivation
| Channel | τdeactivation | P-value | Number of patches | |
| (mean ± SE; ms) | (range; ms) | |||
| Wild-type nAChR | 1.12 ± 0.10 | 0.77–1.71 | 1.0 × 10−15 | 12 |
| αL9′A AChR | 100 ± 5 | 88.9–112 | 4 | |
| Wild-type GLIC | 0.91 ± 0.20 | 0.41–1.91 | – | 11 |
| I9′A GLICa | 162 | 155; 169 | 2 | |
| Wild-type ELIC | 17.2 ± 3.2 | 7.34–26.3 | – | 6 |
| L9′A ELIC | 5.01 ± 0.95 | 4.02–9.23 | 2.7 × 10−3 | 6 |
| L9′A + F16′L ELIC | 5.11 ± 1.04 | 4.01–9.61 | 3.0 × 10−3 | 6 |
| L9′Q ELIC | 15.3 ± 1.9 | 8.75–18.4 | 0.60 | 6 |
| L9′E ELIC | 12.6 ± 0.9 | 10.4–15.3 | 0.17 | 6 |
| Channel | τdeactivation | P-value | Number of patches | |
| (mean ± SE; ms) | (range; ms) | |||
| Wild-type nAChR | 1.12 ± 0.10 | 0.77–1.71 | 1.0 × 10−15 | 12 |
| αL9′A AChR | 100 ± 5 | 88.9–112 | 4 | |
| Wild-type GLIC | 0.91 ± 0.20 | 0.41–1.91 | – | 11 |
| I9′A GLICa | 162 | 155; 169 | 2 | |
| Wild-type ELIC | 17.2 ± 3.2 | 7.34–26.3 | – | 6 |
| L9′A ELIC | 5.01 ± 0.95 | 4.02–9.23 | 2.7 × 10−3 | 6 |
| L9′A + F16′L ELIC | 5.11 ± 1.04 | 4.01–9.61 | 3.0 × 10−3 | 6 |
| L9′Q ELIC | 15.3 ± 1.9 | 8.75–18.4 | 0.60 | 6 |
| L9′E ELIC | 12.6 ± 0.9 | 10.4–15.3 | 0.17 | 6 |
High-quality recordings could only be obtained from two outside-out patches. Hence, neither the standard error nor the p-value was calculated.