Data collection and refinement statistics
| ELIC + cysteamine + lidocaine | ELIC + cysteamine + brominated analog | ELIC + cysteamine + brominated analog | |
| Data collection Space group | P21 | P21 | P21 |
| Wavelength (Å) | 0.97872 | 0.97872 | 0.91838 |
| Cell dimensions | |||
| a, b, c (Å) | 104.96, 266.74, 110.60 | 105.58, 267.78, 110.43 | 105.89, 267.96, 110.29 |
| α, β, γ (°) | 90, 109.15, 90 | 90, 110.82, 90 | 90, 109.53, 90 |
| Resolution (Å) | 50–3.65 (3.78–3.65) | 50–4.23 (4.38–4.23) | 50–4.82 (4.99–4.82) |
| Rsym | 0.123 (0.653) | 0.112 (>1.0) | 0.103 (0.716) |
| Rmeas | 0.134 (0.745) | 0.122 (>1.0) | 0.122 (0.856) |
| Rpim | 0.051 (0.348) | 0.069 (0.989) | 0.065 (0.472) |
| I/σ(I) | 13.6 (1.6) | 8.6 (1.2) | 10.4 (1.1) |
| Completeness (%) | 98.9 (77.9) | 97.9 (96.7) | 96.3 (94.0) |
| Multiplicity | 6.8 (3.5) | 5.9 (4.9) | 3.4 (2.9) |
| Refinement | |||
| Resolution (Å) | 49.58–3.65 | 48.75–4.23 | |
| No. unique reflections | 57,179 | 18,141 | |
| Rwork | 0.235 | 0.256 | |
| Rfree | 0.239 | 0.280 | |
| Rmsd values | |||
| Bond lengths (Å) | 0.006 | 0.003 | |
| Bond angles (°) | 1.18 | 0.831 | |
| No. atoms | |||
| Protein | 25,050 | 25,050 | |
| Ligand | 36 | 80 | |
| Ramachandran plot | |||
| Favored (%) | 88.3 | 87.6 | |
| Outliers (%) | 3.5 | 3.3 |
| ELIC + cysteamine + lidocaine | ELIC + cysteamine + brominated analog | ELIC + cysteamine + brominated analog | |
| Data collection Space group | P21 | P21 | P21 |
| Wavelength (Å) | 0.97872 | 0.97872 | 0.91838 |
| Cell dimensions | |||
| a, b, c (Å) | 104.96, 266.74, 110.60 | 105.58, 267.78, 110.43 | 105.89, 267.96, 110.29 |
| α, β, γ (°) | 90, 109.15, 90 | 90, 110.82, 90 | 90, 109.53, 90 |
| Resolution (Å) | 50–3.65 (3.78–3.65) | 50–4.23 (4.38–4.23) | 50–4.82 (4.99–4.82) |
| Rsym | 0.123 (0.653) | 0.112 (>1.0) | 0.103 (0.716) |
| Rmeas | 0.134 (0.745) | 0.122 (>1.0) | 0.122 (0.856) |
| Rpim | 0.051 (0.348) | 0.069 (0.989) | 0.065 (0.472) |
| I/σ(I) | 13.6 (1.6) | 8.6 (1.2) | 10.4 (1.1) |
| Completeness (%) | 98.9 (77.9) | 97.9 (96.7) | 96.3 (94.0) |
| Multiplicity | 6.8 (3.5) | 5.9 (4.9) | 3.4 (2.9) |
| Refinement | |||
| Resolution (Å) | 49.58–3.65 | 48.75–4.23 | |
| No. unique reflections | 57,179 | 18,141 | |
| Rwork | 0.235 | 0.256 | |
| Rfree | 0.239 | 0.280 | |
| Rmsd values | |||
| Bond lengths (Å) | 0.006 | 0.003 | |
| Bond angles (°) | 1.18 | 0.831 | |
| No. atoms | |||
| Protein | 25,050 | 25,050 | |
| Ligand | 36 | 80 | |
| Ramachandran plot | |||
| Favored (%) | 88.3 | 87.6 | |
| Outliers (%) | 3.5 | 3.3 |