Effect of quaternary-ammonium cations and lidocaine on the time course of current decay upon sustained exposure to agonist
| Channel | Conditions | τdecay | P-value | Number of patches | |
| (mean ± SE; ms) | (range; ms) | ||||
| Wild-type nAChR | Control | 37.0 ± 8.8 | 16.7–63.7 | 0.37 | 6 |
| 0.5 mM TEA+ | 41.2 ± 10.5 | 23.9–74.6 | |||
| Wild-type nAChR | Control | 48.9 ± 6.8 | 22.8–61.9 | 0.11 | 6 |
| 5 mM TEA+ | 59.5 ± 5.5 | 42.3–73.8 | |||
| Wild-type nAChR | Control | 59.8 ± 3.7 | 51.9–67.1 | 7.6 × 10−7 | 4 |
| 0.5 mM lidocaine | 0.60 ± 0.07 | 0.45–0.71 | |||
| Wild-type GLIC | Control | 2,197 ± 950 | 154–3,928 | 0.34 | 6 |
| 5 mM TEA+ | 1,749 ± 737 | 146–4,057 | |||
| Wild-type GLIC | Control | 2,072 ± 452 | 195–5,360 | 4.3 × 10−3 | 12 |
| 0.5 mM lidocaine | 698 ± 208 | 36.7–2,045 | |||
| Wild-type ELIC | Control | 4,533 ± 584 | 2,397–8,026 | – | 9 |
| 50 mM TEA+ | 5,353 ± 988 | 2,443–10,324 | 0.22 | 8 | |
| 5 mM TEA+ (pipette) | 5,370 ± 531 | 3,979–6,677 | 0.16 | 5 | |
| 5 mM lidocaine | unmeasurably slow | – | – | 14 | |
| 50 mM TMA+ | 4,726 ± 782 | 1,608–7,725 | 0.84 | 9 | |
| L9′A + F16′L ELIC | Control | unmeasurably slow | – | – | 17 |
| 50 mM TEA+ | unmeasurably slow | – | – | 7 | |
| 50 mM TMA+ | unmeasurably slow | – | – | 11 | |
| Channel | Conditions | τdecay | P-value | Number of patches | |
| (mean ± SE; ms) | (range; ms) | ||||
| Wild-type nAChR | Control | 37.0 ± 8.8 | 16.7–63.7 | 0.37 | 6 |
| 0.5 mM TEA+ | 41.2 ± 10.5 | 23.9–74.6 | |||
| Wild-type nAChR | Control | 48.9 ± 6.8 | 22.8–61.9 | 0.11 | 6 |
| 5 mM TEA+ | 59.5 ± 5.5 | 42.3–73.8 | |||
| Wild-type nAChR | Control | 59.8 ± 3.7 | 51.9–67.1 | 7.6 × 10−7 | 4 |
| 0.5 mM lidocaine | 0.60 ± 0.07 | 0.45–0.71 | |||
| Wild-type GLIC | Control | 2,197 ± 950 | 154–3,928 | 0.34 | 6 |
| 5 mM TEA+ | 1,749 ± 737 | 146–4,057 | |||
| Wild-type GLIC | Control | 2,072 ± 452 | 195–5,360 | 4.3 × 10−3 | 12 |
| 0.5 mM lidocaine | 698 ± 208 | 36.7–2,045 | |||
| Wild-type ELIC | Control | 4,533 ± 584 | 2,397–8,026 | – | 9 |
| 50 mM TEA+ | 5,353 ± 988 | 2,443–10,324 | 0.22 | 8 | |
| 5 mM TEA+ (pipette) | 5,370 ± 531 | 3,979–6,677 | 0.16 | 5 | |
| 5 mM lidocaine | unmeasurably slow | – | – | 14 | |
| 50 mM TMA+ | 4,726 ± 782 | 1,608–7,725 | 0.84 | 9 | |
| L9′A + F16′L ELIC | Control | unmeasurably slow | – | – | 17 |
| 50 mM TEA+ | unmeasurably slow | – | – | 7 | |
| 50 mM TMA+ | unmeasurably slow | – | – | 11 | |