Table 1.

Single-channel parameters for GluN1/GluN2A receptors in several glycine concentrations

[Glycine] n Amplitude Poa MOTb MCTb Events analyzed 
µM  pA  ms ms  
0.1 3 9.2 ± 0.2 0.08 ± 0.01 6.1 ± 0.9 57 ± 14c 3.5 × 105 
0.2 3 8.9 ± 0.7 0.16 ± 0.05 6.7 ± 0.8 31 ± 4c 7.3 × 105 
0.4 3 9.5 ± 0.5 0.29 ± 0.03 6.2 ± 0.5 14 ± 1c 9.7 × 105 
100 14 8.9 ± 0.3 0.52 ± 0.03 7.1 ± 0.6 6.5 ± 0.7 3.4 × 106 
[Glycine] n Amplitude Poa MOTb MCTb Events analyzed 
µM  pA  ms ms  
0.1 3 9.2 ± 0.2 0.08 ± 0.01 6.1 ± 0.9 57 ± 14c 3.5 × 105 
0.2 3 8.9 ± 0.7 0.16 ± 0.05 6.7 ± 0.8 31 ± 4c 7.3 × 105 
0.4 3 9.5 ± 0.5 0.29 ± 0.03 6.2 ± 0.5 14 ± 1c 9.7 × 105 
100 14 8.9 ± 0.3 0.52 ± 0.03 7.1 ± 0.6 6.5 ± 0.7 3.4 × 106 

All values are mean ± SEM.

a

Values were calculated with full models in MIL.

b

Values were calculated with two-state models in SKM.

c

Significant differences relative to 100 µM (P < 0.00002; Student’s t test).

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