Table 1. Parameters of the aHTG model... | Rockefeller University Press

Table 1.

Parameters of the aHTG model

Parameter	Value	Description
K_Ca (µM)	0.6^a	Ca²⁺ dissociation constant of the ion-free closed state C00
K_Mg (µM)	126.5^b	Mg²⁺ dissociation constant of the ion-free closed state C00
f_Ca	0.046^a	Allosteric factor coupling Ca²⁺ binding to channel opening
f_Mg	0.902^b	Allosteric factor coupling Mg²⁺ binding to channel opening
K_O₀₀	10,800^a	Equilibrium constant of the O00–C00 transition
K_OL	0.5^a	Dissociation constant of the L-mode open state OL
K_CL	0.89^a	Dissociation constant of the L-mode closed state CL
K_CI	3.0^a	Dissociation constant of the inactivated state I
K_I (µM)	760^b	Mg²⁺ dissociation constant of the divalent inhibitory site
[Mg²⁺] (µM)	1,000^a	Free Mg²⁺ concentration
τ_o (ms)	15^a	Mean RyR open time
p_dis	0.39^b	Probability of Mg²⁺ dissociation from activation site during the spark

Parameter	Value	Description
K_Ca (µM)	0.6^a	Ca²⁺ dissociation constant of the ion-free closed state C00
K_Mg (µM)	126.5^b	Mg²⁺ dissociation constant of the ion-free closed state C00
f_Ca	0.046^a	Allosteric factor coupling Ca²⁺ binding to channel opening
f_Mg	0.902^b	Allosteric factor coupling Mg²⁺ binding to channel opening
K_O₀₀	10,800^a	Equilibrium constant of the O00–C00 transition
K_OL	0.5^a	Dissociation constant of the L-mode open state OL
K_CL	0.89^a	Dissociation constant of the L-mode closed state CL
K_CI	3.0^a	Dissociation constant of the inactivated state I
K_I (µM)	760^b	Mg²⁺ dissociation constant of the divalent inhibitory site
[Mg²⁺] (µM)	1,000^a	Free Mg²⁺ concentration
τ_o (ms)	15^a	Mean RyR open time
p_dis	0.39^b	Probability of Mg²⁺ dissociation from activation site during the spark

Data from Zahradníková et al., 2010.

Data from Zahradníková and Zahradník, 2012.