Table 2. Biophysical parameters of Na v... | Rockefeller University Press

Table 2.

Biophysical parameters of Na_v1.5/WT, R222Q, and R225W

Biophysical parameters	WT (n = 9)	R222Q (n = 13)	R225W (n = 11)
Peak Current (pA/pF)	−186.5 ± 21.0	−285.5 ± 29.4^a	−32.3 ± 4.2^b
Normalized G_max (pS/pF)	3.1 ± 0.4	4.0 ± 0.3	0.6 ± 0.1b
Activation
V_1/2 (mV)	−48.9 ± 1.3	−61.8 ± 2.1^b	−37.0 ± 1.1^b
k (mV)	−6.6 ± 0.5	−5.7 ± 0.5	−12.0 ± 0.3^b
Inactivation
V_1/2 (mV)	−93.2 ± 1.7	−97.8 ± 2.0	−89.3 ± 0.9^a
k (mV)	5.0 ± 0.2	4.8 ± 0.1	5.4 ± 0.3
Recovery from inactivation
τ (ms)	3.2 ± 0.3	3.1 ± 0.3	2.4 ± 0.2^a
Peak ramp current (% peak current)	−2.7 ± 0.3	−4.2 ± 0.5^a	−9.4 ± 0.5^b
Peak ramp current (pA/pF)	−4.6 ± 0.8	−12.7 ± 2.7^a	−2.3 ± 0.3^a

Biophysical parameters	WT (n = 9)	R222Q (n = 13)	R225W (n = 11)
Peak Current (pA/pF)	−186.5 ± 21.0	−285.5 ± 29.4^a	−32.3 ± 4.2^b
Normalized G_max (pS/pF)	3.1 ± 0.4	4.0 ± 0.3	0.6 ± 0.1b
Activation
V_1/2 (mV)	−48.9 ± 1.3	−61.8 ± 2.1^b	−37.0 ± 1.1^b
k (mV)	−6.6 ± 0.5	−5.7 ± 0.5	−12.0 ± 0.3^b
Inactivation
V_1/2 (mV)	−93.2 ± 1.7	−97.8 ± 2.0	−89.3 ± 0.9^a
k (mV)	5.0 ± 0.2	4.8 ± 0.1	5.4 ± 0.3
Recovery from inactivation
τ (ms)	3.2 ± 0.3	3.1 ± 0.3	2.4 ± 0.2^a
Peak ramp current (% peak current)	−2.7 ± 0.3	−4.2 ± 0.5^a	−9.4 ± 0.5^b
Peak ramp current (pA/pF)	−4.6 ± 0.8	−12.7 ± 2.7^a	−2.3 ± 0.3^a

V_1/2, midpoint for activation or inactivation; k, slow factor for activation or inactivation. For all values, n > 6.

Difference between Na_v1.5/WT; P < 0.05.

P < 0.001.