Table 2. IC 50 values for gliclazide... | Rockefeller University Press

Table 2.

IC₅₀ values for gliclazide concentration-inhibition relationships of the indicated K_ATP channels

Channel	Nucleotide	No nucleotide	+Nucleotide
Kir6.2/SUR1	100 µM MgADP	77 ± 11 nM (n = 6)	245 ± 29 nM^a (n = 6)
Kir.2/SUR2A-YS	100 µM MgADP	1.2 ± 0.2 µM (n = 5)	2.3 ± 0.6 µM (n = 5)
Kir6.2-G334D/SUR1	1 mM MgATP	72 ± 12 nM (n = 6)	240 ± 42 nM^a (n = 6)
Kir.2-G334D/SUR2A-YS	1 mM MgATP	1.6 ± 0.5 µM (n = 5)	2.9 ± 1.1 µM (n = 5)

Channel	Nucleotide	No nucleotide	+Nucleotide
Kir6.2/SUR1	100 µM MgADP	77 ± 11 nM (n = 6)	245 ± 29 nM^a (n = 6)
Kir.2/SUR2A-YS	100 µM MgADP	1.2 ± 0.2 µM (n = 5)	2.3 ± 0.6 µM (n = 5)
Kir6.2-G334D/SUR1	1 mM MgATP	72 ± 12 nM (n = 6)	240 ± 42 nM^a (n = 6)
Kir.2-G334D/SUR2A-YS	1 mM MgATP	1.6 ± 0.5 µM (n = 5)	2.9 ± 1.1 µM (n = 5)

All values are the mean of the fits to the individual dose–response curves.

P < 0.01 against 0 mM nucleotide (by Student’s t test).