Table 4.

The Hill fit parameters for cytoplasmic Ca2+ activation of RyR2 in the presence of 1 mM Mg2+ shown in Fig. 3 A 

Species Luminal pCa Pmax Pmin Ka Ha n 
    µM   
Activation by cytoplasmic Ca2+ 
Human 0.55 ± 0.10 0a 25 ± 8 2.6 ± 0.6 4–8 
Sheep 0.70 ± 0.10 0a 34 ± 5 2.2 ± 0.2 5–10 
Rat 0.54 ± 0.06 0a 88 ± 9b 3.5 ± 0.4 4–7 
Species Luminal pCa Pmax Pmin Ka Ha n 
    µM   
Activation by cytoplasmic Ca2+ 
Human 0.55 ± 0.10 0a 25 ± 8 2.6 ± 0.6 4–8 
Sheep 0.70 ± 0.10 0a 34 ± 5 2.2 ± 0.2 5–10 
Rat 0.54 ± 0.06 0a 88 ± 9b 3.5 ± 0.4 4–7 

n indicates the number of experiments.

a

Parameters that were not adjusted during fitting.

b

Significantly different to human (P < 0.01).

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