Table 1.

Data collection and refinement statistics

Statistics Protein 
 Ba2+,K+–MthK complex Ba2+,Na+–MthK complex 
Mutations S68H, V77C S68H, V77C 
BaCl2/KCl/NaCl concentration 10 mM/100 mM/0 mM 10 mM/0 mM/100 mM 
Data collection   
Space group P421P421
Unit cell a, c (Å) 61.0, 45.0 61.0, 45.3 
Resolution (Å) 2.15 2.4 
Measured reflections 51,128 42,306 
Unique reflections 4,888 3,576 
Redundancy 10.5 11.8 
Completeness (%) 98.4 (100.0) 97.5 (91.3) 
Mean I/σ 26.6 (2.4) 41.2 (2.1) 
Rsym (%) 10.5 (75.3) 9.2 (72.1) 
Refinement   
Resolution (Å) 50.0–2.15 50.0–2.4 
Rwork/Rfree (%) 19.8/25.7 22.1/26.5 
Number of protein atoms 648 633 
Number of K+ ions 
Number of Na+ ions 
Number of Ba2+ ions 
Number of water molecules 43 28 
RMSD bond lengths (Å) 0.010 0.009 
RMSD bond angles (°) 1.15 1.13 
Statistics Protein 
 Ba2+,K+–MthK complex Ba2+,Na+–MthK complex 
Mutations S68H, V77C S68H, V77C 
BaCl2/KCl/NaCl concentration 10 mM/100 mM/0 mM 10 mM/0 mM/100 mM 
Data collection   
Space group P421P421
Unit cell a, c (Å) 61.0, 45.0 61.0, 45.3 
Resolution (Å) 2.15 2.4 
Measured reflections 51,128 42,306 
Unique reflections 4,888 3,576 
Redundancy 10.5 11.8 
Completeness (%) 98.4 (100.0) 97.5 (91.3) 
Mean I/σ 26.6 (2.4) 41.2 (2.1) 
Rsym (%) 10.5 (75.3) 9.2 (72.1) 
Refinement   
Resolution (Å) 50.0–2.15 50.0–2.4 
Rwork/Rfree (%) 19.8/25.7 22.1/26.5 
Number of protein atoms 648 633 
Number of K+ ions 
Number of Na+ ions 
Number of Ba2+ ions 
Number of water molecules 43 28 
RMSD bond lengths (Å) 0.010 0.009 
RMSD bond angles (°) 1.15 1.13 

Numbers in parentheses are statistics for highest resolution shell. Redundancy = total measurements/unique reflections. Rsym = Σ|Ii – <Ii>|/ΣIi, where <Ii> is the mean intensity of symmetry equivalent reflections. Rwork = Σ|F(obs) – F(cal)|/ΣF(obs). 10% of the data was used in the Rfree calculations. RMSD, root mean square deviation.

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