Table 1. Canonical CaM-binding motifs... | Rockefeller University Press

Table 1.

Canonical CaM-binding motifs

Motif	Sequence
Ca²⁺ dependent
1–10	[FILVW]xxxxxxxx[FILVW]
1–5–10	[FILVW]xxx[FAILVW]xxxx[FILVW]
Basic 1–5–10	[RK][RK][RK][FAILVW]xxx[FILV]xxxx[FILVW]
1–12	[FILVW]xxxxxxxxxx[FILVW]
1–14	[FILVW]xxxxxxxxxxxx[FILVW]
1–8–14	[FILVW]xxxxxx[FAILVW]xxxxx[FILVW]
1–5–8–14	[FILVW]xxx[FAILVW]xx[FAILVW]xxxxx[FILVW]
Basic 1–8–14	[RK][RK][RK][FILVW]xxxxxx[FAILVW]xxxxx[FILVW]
1–16	[FILVW]xxxxxxxxxxxxxx[FILVW]
Ca²⁺ independent
IQ	[FILV]Qxxx[RK]Gxxx[RK]xx[FILVWY]
IQ-like^a	[FILV]Qxxx[RK]xxxxxxxx
IQ-2A	[IVL]QxxxRxxxx[VL][KR]xW
IQ-2B	[IL]QxxCxxxxKxRxW
IQ unconventional	[IVL]QxxxRxxxx[RK]xx[FILVWY]

Motif	Sequence
Ca²⁺ dependent
1–10	[FILVW]xxxxxxxx[FILVW]
1–5–10	[FILVW]xxx[FAILVW]xxxx[FILVW]
Basic 1–5–10	[RK][RK][RK][FAILVW]xxx[FILV]xxxx[FILVW]
1–12	[FILVW]xxxxxxxxxx[FILVW]
1–14	[FILVW]xxxxxxxxxxxx[FILVW]
1–8–14	[FILVW]xxxxxx[FAILVW]xxxxx[FILVW]
1–5–8–14	[FILVW]xxx[FAILVW]xx[FAILVW]xxxxx[FILVW]
Basic 1–8–14	[RK][RK][RK][FILVW]xxxxxx[FAILVW]xxxxx[FILVW]
1–16	[FILVW]xxxxxxxxxxxxxx[FILVW]
Ca²⁺ independent
IQ	[FILV]Qxxx[RK]Gxxx[RK]xx[FILVWY]
IQ-like^a	[FILV]Qxxx[RK]xxxxxxxx
IQ-2A	[IVL]QxxxRxxxx[VL][KR]xW
IQ-2B	[IL]QxxCxxxxKxRxW
IQ unconventional	[IVL]QxxxRxxxx[RK]xx[FILVWY]

Numbers for the Ca²⁺-dependent motifs indicate the positions that require a hydrophobic residue. Residues in the brackets can substitute for each other; x indicates any amino acid residue.

Some IQ-like motifs require Ca²⁺ for CaM binding.

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