Table 1. Parameter estimates for the... | Rockefeller University Press

Table 1.

Parameter estimates for the gating pore conductance

Parameter	Units	WT	R669H	R672G
I_{Na_max}/Q_{on_max}	nA/nC	17,400 ± 110	2,810 ± 360	6,460 ± 730
I_GP/Q_{on_max}	nA/nC	NA	25.6 ± 1.2	99.1 ± 5.5
I_GP/I_{Na_mut}	—	NA	0.0091	0.0155
γ_GP/γ_{Na_WT}	—	NA	0.000174	0.000571
γ_GP: γ_{Na_WT}		NA	1:5, 750	1:1, 750
γ_GP^a	fS	NA	2.95	11.4
Predicated GP conductance in HypoPP muscle
G_GP^b	µS/cm²	NA	4.9	19.0
G_GP/G_total	—	NA	0.005	0.019

Parameter	Units	WT	R669H	R672G
I_{Na_max}/Q_{on_max}	nA/nC	17,400 ± 110	2,810 ± 360	6,460 ± 730
I_GP/Q_{on_max}	nA/nC	NA	25.6 ± 1.2	99.1 ± 5.5
I_GP/I_{Na_mut}	—	NA	0.0091	0.0155
γ_GP/γ_{Na_WT}	—	NA	0.000174	0.000571
γ_GP: γ_{Na_WT}		NA	1:5, 750	1:1, 750
γ_GP^a	fS	NA	2.95	11.4
Predicated GP conductance in HypoPP muscle
G_GP^b	µS/cm²	NA	4.9	19.0
G_GP/G_total	—	NA	0.005	0.019

Assumes γ_{Na_WT} = 20 pS.

Assumes G_{Na_max} = 65 mS/cm² for WT Na_V1.4 in mammalian skeletal muscle.