Muscle resting tension
| Force | Time | C57BL/6 WT (n = 9) | KO (n = 10) | FVB WT (n = 15) | TG (n = 19) |
| min | |||||
| Resting force (mN) (P vs. WT control) | 0 | 78.7 ± 1.5 | 74.8 ± 1.2 (P = NS) | 75.7 ± 0.6 | 77.8 ± 2.4 (P = NS) |
| Δ versus baseline (P vs. baseline) | 7 | −8.7 ± 1.7 | −5.8 ± 3.1 (P = NS) | −6.3 ± 0.6 | −2.3 ± 1.4 (P = NS) |
| Force | Time | C57BL/6 WT (n = 9) | KO (n = 10) | FVB WT (n = 15) | TG (n = 19) |
| min | |||||
| Resting force (mN) (P vs. WT control) | 0 | 78.7 ± 1.5 | 74.8 ± 1.2 (P = NS) | 75.7 ± 0.6 | 77.8 ± 2.4 (P = NS) |
| Δ versus baseline (P vs. baseline) | 7 | −8.7 ± 1.7 | −5.8 ± 3.1 (P = NS) | −6.3 ± 0.6 | −2.3 ± 1.4 (P = NS) |
Resting tension of in situ TA muscle is measured at time 0 (baseline) and at 7-min duration of the 1-Hz isometric twitching protocol. KO and TG mice are compared with their respective C57BL/6 and FVB controls. Measurements at time 7 min are expressed as the difference versus measurements at time 0 (p-values are for KO or TG vs. their WT controls using Student’s t test).