Table 2. Summary of half-maximal... | Rockefeller University Press

Table 2.

Summary of half-maximal inhibitory concentration (IC₅₀) and Hill slope values in HEK cells stably expressing human Ca_v2.1 or Ca_v2.3c channels and transiently coexpressing GABA_BRs

Agonist	Ca_v2.1 and GABA_BR		Ca_v2.3c and GABA_BR
	IC₅₀	Hill slope	IC₅₀	Hill slope
	nM		nM
Baclofen	470 ± 34 (5)	0.73 ± 0.05	330 ± 72 (7)	0.75 ± 0.14
GABA	388 ± 17 (4)	0.76 ± 0.20	328 ± 102 (4)	0.75 ± 0.24
c-Vc1.1	—	—	0.29 ± 0.08 (4–7)^a	0.61 ± 0.14

Agonist	Ca_v2.1 and GABA_BR		Ca_v2.3c and GABA_BR
	IC₅₀	Hill slope	IC₅₀	Hill slope
	nM		nM
Baclofen	470 ± 34 (5)	0.73 ± 0.05	330 ± 72 (7)	0.75 ± 0.14
GABA	388 ± 17 (4)	0.76 ± 0.20	328 ± 102 (4)	0.75 ± 0.24
c-Vc1.1	—	—	0.29 ± 0.08 (4–7)^a	0.61 ± 0.14

Values represent mean ± SEM; n, number of experiments in parentheses; see details of the fitting procedure in Materials and methods.

Each data point (Fig. 2 F) was obtained from four to seven individual experiments.

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