Table 1.
Parameters of Ca
2+
blockade of Na
+
Orai3 currents
Channel type
K
i
n
kon
koff
Unitary current
µM
M
−1
s
−1
s
−1
fA
Orai3 (STIM1-gated)
25
1.2
4 × 10
6
33
71
Orai3 (2-APB–gated)
26
1.2
3 × 10
7
246
283
E81D Orai3 (STIM1-gated)
111
1.0
4 × 10
5
130
–
E81D Orai3 (2-APB–gated)
154
1.0
–
–
–
E165A Orai3 (2-APB–gated)
32
1.2
–
–
–
Channel type
K
i
n
kon
koff
Unitary current
µM
M
−1
s
−1
s
−1
fA
Orai3 (STIM1-gated)
25
1.2
4 × 10
6
33
71
Orai3 (2-APB–gated)
26
1.2
3 × 10
7
246
283
E81D Orai3 (STIM1-gated)
111
1.0
4 × 10
5
130
–
E81D Orai3 (2-APB–gated)
154
1.0
–
–
–
E165A Orai3 (2-APB–gated)
32
1.2
–
–
–
–, not determined.
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