Table 2. Equations for channel gating... | Rockefeller University Press

Table 2.

Equations for channel gating

Comment to the equation	Equation	No.
Open probability in DG model:	$P_{o} = {(K_{1} \cdot K_{2} / d {[DAG]}^{2} + K_{2} / d [DAG] + 1)}^{- 1}$	18
Open probability in SPD model:	$\begin{array}{l} P_{o} = {[\begin{array}{l} K_{1} \cdot K_{2} / d {[DAG]}^{2} + K_{2} / d [DAG] + (K_{1} \cdot K_{2} / d {[DAG]}^{2}) \cdot (K_{3} / d[PI (4, 5) P_{2}]_{tot}) \\ + K_{2} \cdot (K_{3} / d {[PI (4, 5) P_{2}]}_{tot}) / d [DAG] + (K_{3} / d {[PI (4, 5) P_{2}]}_{tot}) + 1 \end{array}]}^{- 1} \\ K_{1} and K_{2} are dissociation constants for DAG to TRPC channel . \\ K_{3} is dissociation constant for PI (4, 5) P_{2} to TRPC channel . \end{array}$	19
TRPC6 / C7 currents:	$\begin{array}{l} I = N \cdot g \cdot P_{o} \cdot (V_{h} - V_{r e v}) \\ N : number of channels \\ g : single channel conductance \\ V_{h} : holding potential (- 50 mV) \\ V_{r e v} : reversal potential (0 mV) \end{array}$	20