Table 2.
Equations for channel gating
Comment to the equation
Equation
No.
Open probability in DG model:
P
o
=
(
K
1
·
K
2
/
d
[
DAG
]
2
+
K
2
/
d
[
DAG
]
+
1
)
−
1
18
Open probability in SPD model:
P
o
=
[
K
1
·
K
2
/
d
[
DAG
]
2
+
K
2
/
d
[
DAG
]
+
(
K
1
·
K
2
/
d
[
DAG
]
2
)
·
(
K
3
/
d[PI
(
4
,
5
)
P
2
]
tot
)
+
K
2
·
(
K
3
/
d
[
PI
(
4
,
5
)
P
2
]
tot
)
/
d
[
DAG
]
+
(
K
3
/
d
[
PI
(
4
,
5
)
P
2
]
tot
)
+
1
]
−
1
K
1
and
K
2
are dissociation constants for DAG to TRPC channel
.
K
3
is dissociation constant for PI
(
4
,
5
)
P
2
to TRPC channel
.
19
TRPC6 / C7 currents:
I
=
N
·
g
·
P
o
·
(
V
h
−
V
r
e
v
)
N
:
number of channels
g
:
single channel conductance
V
h
:
holding potential
(
−
50
mV
)
V
r
e
v
:
reversal potential
(
0
mV
)
20
Comment to the equation
Equation
No.
Open probability in DG model:
P
o
=
(
K
1
·
K
2
/
d
[
DAG
]
2
+
K
2
/
d
[
DAG
]
+
1
)
−
1
18
Open probability in SPD model:
P
o
=
[
K
1
·
K
2
/
d
[
DAG
]
2
+
K
2
/
d
[
DAG
]
+
(
K
1
·
K
2
/
d
[
DAG
]
2
)
·
(
K
3
/
d[PI
(
4
,
5
)
P
2
]
tot
)
+
K
2
·
(
K
3
/
d
[
PI
(
4
,
5
)
P
2
]
tot
)
/
d
[
DAG
]
+
(
K
3
/
d
[
PI
(
4
,
5
)
P
2
]
tot
)
+
1
]
−
1
K
1
and
K
2
are dissociation constants for DAG to TRPC channel
.
K
3
is dissociation constant for PI
(
4
,
5
)
P
2
to TRPC channel
.
19
TRPC6 / C7 currents:
I
=
N
·
g
·
P
o
·
(
V
h
−
V
r
e
v
)
N
:
number of channels
g
:
single channel conductance
V
h
:
holding potential
(
−
50
mV
)
V
r
e
v
:
reversal potential
(
0
mV
)
20
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