Table 3. Allosteric model parameters for... | Rockefeller University Press

Table 3.

Allosteric model parameters for I696X in the absence of capsaicin

Channel	J₀	z_g	L	D	ΔG_o
					kcal/mol
TRPV1	0.021	0.60	0.00053	4,500	1.7
I696V	0.018	0.60	0.00047	8,500	1.5
I696L	0.019	0.60	0.00050	6,000	1.6
I696M	0.018	0.62	0.00049	2,000	2.1
I696H	0.021	0.60	0.00049	4,000	1.8

Channel	J₀	z_g	L	D	ΔG_o
					kcal/mol
TRPV1	0.021	0.60	0.00053	4,500	1.7
I696V	0.018	0.60	0.00047	8,500	1.5
I696L	0.019	0.60	0.00050	6,000	1.6
I696M	0.018	0.62	0.00049	2,000	2.1
I696H	0.021	0.60	0.00049	4,000	1.8

Normalized g-V curves (Fig. 8 A) were fitted to the Eq. 1, and free energies were obtained using Eq. 2.