Single cell response parameters
| Mouse line | Rmax | I1/2 | It | S(f) | τD |
| pA | R* | ms | pA/R* | ms | |
| WT (51) | 12.6 ± 0.4 | 23.0 ± 1.0 | 292 ± 15 | 0.38 ± 0.03 | 172 ± 4 |
| CaMΔ (20) | 11.3 ± 0.9 | 21.0 ± 1.8 | 312 ± 26 | 0.31 ± 0.03 | 168 ± 7 |
| GCAP−/− (15) | 11.4 ± 1.5 | 13.0 ± 1.6 | 470 ± 35 | 1.2 ± 0.2 | 191 ± 7 |
| Mouse line | Rmax | I1/2 | It | S(f) | τD |
| pA | R* | ms | pA/R* | ms | |
| WT (51) | 12.6 ± 0.4 | 23.0 ± 1.0 | 292 ± 15 | 0.38 ± 0.03 | 172 ± 4 |
| CaMΔ (20) | 11.3 ± 0.9 | 21.0 ± 1.8 | 312 ± 26 | 0.31 ± 0.03 | 168 ± 7 |
| GCAP−/− (15) | 11.4 ± 1.5 | 13.0 ± 1.6 | 470 ± 35 | 1.2 ± 0.2 | 191 ± 7 |
Parameters tested for single cell recordings in WT, calmodulin-binding site deletion mice (CaMΔ), and GCAP1 and GCAP2 knockout mice (GCAP−/−). Rmax is the maximum dark-adapted circulating current. I1/2 is the number of activated rhodopsin molecules sufficient to elicit a half-maximal response. It measures integration time of the rods to dim flashes. S(f) represents flash sensitivity in pA/activated rhodopsin. τD is a measure of the dominant time constant of recovery, measured at 75% of maximal response. All measures are mean ±1 SEM.