Table 1. Comparison of computational... | Rockefeller University Press

Table 1.

Comparison of computational models that have predicted mechanisms contributing to cAMP compartmentation

Model	Cell type	cAMP synthesis	cAMP degradation	Physical barriers	cAMP buffers	cAMP export	Cell shape
Rich et al., 2000	HEK293			X
Rich et al., 2001	HEK293		X	X
Rich et al., 2007	HEK293		X	X
Oliveira et al., 2010	HEK293		X
Xie et al., 2011	T84		X	X		X
Sample et al., 2012	HEK293	X	X	X
Saucerman et al., 2006	Cardiac myocyte	X	X	X	X
Iancu et al., 2007	Cardiac myocyte	X	X	X
Heijman et al., 2011	Cardiac myocyte	X	X	X
Neves et al., 2008	Neuron		X				X
Chen et al., 2009	Neuron		X				X
Feinstein et al., 2012	Endothelial cell	X	X	X	X		X
Chen et al., 2008	Idealized	X	X

Model	Cell type	cAMP synthesis	cAMP degradation	Physical barriers	cAMP buffers	cAMP export	Cell shape
Rich et al., 2000	HEK293			X
Rich et al., 2001	HEK293		X	X
Rich et al., 2007	HEK293		X	X
Oliveira et al., 2010	HEK293		X
Xie et al., 2011	T84		X	X		X
Sample et al., 2012	HEK293	X	X	X
Saucerman et al., 2006	Cardiac myocyte	X	X	X	X
Iancu et al., 2007	Cardiac myocyte	X	X	X
Heijman et al., 2011	Cardiac myocyte	X	X	X
Neves et al., 2008	Neuron		X				X
Chen et al., 2009	Neuron		X				X
Feinstein et al., 2012	Endothelial cell	X	X	X	X		X
Chen et al., 2008	Idealized	X	X