Table 1.

Known AKAPs and their binding partners

Gene name Protein names and Isoforms Binding partners Targeting motifs/localization 
AKAP1 D-AKAP, s-AKAP84, AKAP121, AKAP149 PKA I and II, protein tyrosine phosphatase PTPD1, Src, PKCα, Lfc, PDE7A, RSK1, PP1, PP2A, CaN, mRNA, AMY-1, lamin-B, HIV-1 RT Mitochondrion, endoplasmic reticulum, nuclear envelope 
AKAP2 AKAP-KL aquaporin-0, PKAII Lens, apical surface of epithelial cells 
AKAP5 AKAP79, AKAP75, AKAP150 PKAII, PKC, CaN, KCNQ2, CaV1, β1-AR, AC, SAP-97, PP1, GluR1, mGluR1/5, PSD-95, AC5/6, PP2B, Kir2.1, ASIC1a/2a, TRPV1, NMDAR, IQGAP1 Plasmalemma and T-tubules, post 
AKAP6 mAKAPβ PKAII, AC5, PDE4D3, PP2A B56δ, RyR2, CaNAβ, NFATc, HIF-1a, VHL, Siah2, Epac1, Rap1, ERK5, MEK5, RSK3, PDK1, NCX1, nesprin-1α, myopodin Nuclear envelope 
AKAP7 AKAP15, AKAP18 (α, β, γ, δ) PKAII, CaV1, NaV1.2a channel, phospholamban, inhibitor-1, PP1, PKC, AQP2, 5′-AMP Plasmalemma and sarcoplasmic reticulum, nuclear (δ NLS), plasma membrane (α and β myristolyation, dual palmitoylation) 
AKAP8 AKAP95 PKAII, PDE7A, MCM2, p68 RNA helicase, HDAC3, AMY-1, cyclin D/E, condensin Nucleus 
AKAP9 Yotiao, AKAP450, AKAP350, CG-NAP, Hyperion PKAII, AC, PP1, PP2A, PDE4D3, KCNQ1, IP3R, PKCε, PKN, casein kinase 1, chloride intracellular channel (CLIC), NMDAR, GCP2/3 Plasmalemma, centrosomes, Golgi 
AKAP10 D-AKAP2 PKA I and II, Rab11, Rab4, PDZK1, PP1, RSK1 Outer mitochodrial membrane 
AKAP11 AKAP220 PKAII, PP1, GSK3β, GABACR, AQP2 Peroxisomes 
AKAP12 Gravin, SSeCKS PKAII, PDE4D3, PKC Src, CaN, β2-AR, calmodulin, cyclin D Actin cytoskeleton, plasma membrane (myristolyaltion) 
AKAP13 AKAP-Lbc, Ht31, BRX-1 PKAII, Gα12, Rho, PKNα, MLTK, MKK3, p38α, KSR1, Raf, MEK1/2, ERK1/2, 14-3-3, PKCη, PKD, SHp2, HSP20, α-catulin, LC3 Cytoskeleton 
ARGEF2 BIG2 PKA I and II, formin-binding protein 3, PDE3A, TNFR1 Cytoplasm, internal membranes including Golgi 
EZR Ezrin PKAI and II, CFTR, EBP50/NHERF, NHE3, calmodulin, Rho kinase, actin, α1AR, E-cadherin, β-catenin, EGFR, Fas-R, PKCα, S100, FAK, SAP-97, moesin, radixin, FAK, merlin Cytoskeleton 
MAP2 MAP2B PKAII, tubulin, CaV1, myosin VIIa Microtubules 
CMYA5 Myospryn PKAII, dysbindin, titin, calpain-3, desmin, dystrophin Sarcomere 
SPHKAP SKIP PKAI, sphingosine kinase type 1 Cytosol 
SYNM Synemin PKAII, desmin, vimentin, dystrobrevin, desmuslin, zyxin, talin, vinculin Intercalated discs, sarcolemma, Z-lines, intermediate filaments 
TNNT2 Troponin T Troponin I, troponin C, actin Sarcomere thin filaments 
LDB3 Cypher, ZASP PKAII, CaN, L-type calcium channel Sacomere Z-lines 
C2orf88 smAKAP PKAI Cell–cell junctions, filipodia 
PCNT Pericentrin PKAII, calmodulin, y-tubulin Centrosome 
WASF-1 Wave-1 PKAII, actin nucleation core Arp2/3 complex, BAIAP2, profilin 1 Actin cytoskeleton 
ACBD3 PAP7 giantin, PPM1L, PKAI Mitochondria 
NBEA Neurobechin SAP102, PKA Golgi 
AKAP14 Akap28 PKAII Ciliary axonemes 
CBFA2T3 Myeloid translocation gene (MTG) 8 and 16b plexin, PKAI and PKAII Golgi 
RAB32 Rab32 PKAII Mitochondria 
MYRIP Myosin-VIIa- and Rab-interacting protein myosin VA Perinuclear 
NF2 Merlin PKAI, PKAII, HGS, ezrin, cullin-4A, syntenin-1, VPRBP, RIT1, SPTBN1, MED28, DDB1 Soma, dendrites 
AKAP17A SFRS17A PKAI, PKAII Nucleus 
Gene name Protein names and Isoforms Binding partners Targeting motifs/localization 
AKAP1 D-AKAP, s-AKAP84, AKAP121, AKAP149 PKA I and II, protein tyrosine phosphatase PTPD1, Src, PKCα, Lfc, PDE7A, RSK1, PP1, PP2A, CaN, mRNA, AMY-1, lamin-B, HIV-1 RT Mitochondrion, endoplasmic reticulum, nuclear envelope 
AKAP2 AKAP-KL aquaporin-0, PKAII Lens, apical surface of epithelial cells 
AKAP5 AKAP79, AKAP75, AKAP150 PKAII, PKC, CaN, KCNQ2, CaV1, β1-AR, AC, SAP-97, PP1, GluR1, mGluR1/5, PSD-95, AC5/6, PP2B, Kir2.1, ASIC1a/2a, TRPV1, NMDAR, IQGAP1 Plasmalemma and T-tubules, post 
AKAP6 mAKAPβ PKAII, AC5, PDE4D3, PP2A B56δ, RyR2, CaNAβ, NFATc, HIF-1a, VHL, Siah2, Epac1, Rap1, ERK5, MEK5, RSK3, PDK1, NCX1, nesprin-1α, myopodin Nuclear envelope 
AKAP7 AKAP15, AKAP18 (α, β, γ, δ) PKAII, CaV1, NaV1.2a channel, phospholamban, inhibitor-1, PP1, PKC, AQP2, 5′-AMP Plasmalemma and sarcoplasmic reticulum, nuclear (δ NLS), plasma membrane (α and β myristolyation, dual palmitoylation) 
AKAP8 AKAP95 PKAII, PDE7A, MCM2, p68 RNA helicase, HDAC3, AMY-1, cyclin D/E, condensin Nucleus 
AKAP9 Yotiao, AKAP450, AKAP350, CG-NAP, Hyperion PKAII, AC, PP1, PP2A, PDE4D3, KCNQ1, IP3R, PKCε, PKN, casein kinase 1, chloride intracellular channel (CLIC), NMDAR, GCP2/3 Plasmalemma, centrosomes, Golgi 
AKAP10 D-AKAP2 PKA I and II, Rab11, Rab4, PDZK1, PP1, RSK1 Outer mitochodrial membrane 
AKAP11 AKAP220 PKAII, PP1, GSK3β, GABACR, AQP2 Peroxisomes 
AKAP12 Gravin, SSeCKS PKAII, PDE4D3, PKC Src, CaN, β2-AR, calmodulin, cyclin D Actin cytoskeleton, plasma membrane (myristolyaltion) 
AKAP13 AKAP-Lbc, Ht31, BRX-1 PKAII, Gα12, Rho, PKNα, MLTK, MKK3, p38α, KSR1, Raf, MEK1/2, ERK1/2, 14-3-3, PKCη, PKD, SHp2, HSP20, α-catulin, LC3 Cytoskeleton 
ARGEF2 BIG2 PKA I and II, formin-binding protein 3, PDE3A, TNFR1 Cytoplasm, internal membranes including Golgi 
EZR Ezrin PKAI and II, CFTR, EBP50/NHERF, NHE3, calmodulin, Rho kinase, actin, α1AR, E-cadherin, β-catenin, EGFR, Fas-R, PKCα, S100, FAK, SAP-97, moesin, radixin, FAK, merlin Cytoskeleton 
MAP2 MAP2B PKAII, tubulin, CaV1, myosin VIIa Microtubules 
CMYA5 Myospryn PKAII, dysbindin, titin, calpain-3, desmin, dystrophin Sarcomere 
SPHKAP SKIP PKAI, sphingosine kinase type 1 Cytosol 
SYNM Synemin PKAII, desmin, vimentin, dystrobrevin, desmuslin, zyxin, talin, vinculin Intercalated discs, sarcolemma, Z-lines, intermediate filaments 
TNNT2 Troponin T Troponin I, troponin C, actin Sarcomere thin filaments 
LDB3 Cypher, ZASP PKAII, CaN, L-type calcium channel Sacomere Z-lines 
C2orf88 smAKAP PKAI Cell–cell junctions, filipodia 
PCNT Pericentrin PKAII, calmodulin, y-tubulin Centrosome 
WASF-1 Wave-1 PKAII, actin nucleation core Arp2/3 complex, BAIAP2, profilin 1 Actin cytoskeleton 
ACBD3 PAP7 giantin, PPM1L, PKAI Mitochondria 
NBEA Neurobechin SAP102, PKA Golgi 
AKAP14 Akap28 PKAII Ciliary axonemes 
CBFA2T3 Myeloid translocation gene (MTG) 8 and 16b plexin, PKAI and PKAII Golgi 
RAB32 Rab32 PKAII Mitochondria 
MYRIP Myosin-VIIa- and Rab-interacting protein myosin VA Perinuclear 
NF2 Merlin PKAI, PKAII, HGS, ezrin, cullin-4A, syntenin-1, VPRBP, RIT1, SPTBN1, MED28, DDB1 Soma, dendrites 
AKAP17A SFRS17A PKAI, PKAII Nucleus 
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