Single MT channel currents in mouse OHCs
| Mice | Location | I channel | G channel | n traces | n cells, age |
| pA | pS | ||||
| Wild type | Apex | 5.2 ± 0.1a,b | 62 | 50 | 5, P4–P5 |
| Tmc1+/− | Apex | 5.3 ± 0.1 | 63 | 41 | 4, P4 |
| Tmc1−/− | Apex | 4.1 ± 0.1a | 49 | 93 | 6, P4–P5 |
| Tmc2+/− | Apex | 5.5 ± 0.3 | 65 | 13 | 4, P4 |
| Tmc2−/− | Apex | 5.2 ± 0.2 | 62 | 14 | 4, P4 |
| Tmc1−/−Tmc2−/− | Apex | 5.5 ± 0.1 | 65 | 56 | 4, P5–P6 |
| Tmc1−/−Tmc2−/− | Apex | 2.1 ± 0.03c | 25 | 8 | 3, P6 |
| Wild type | Base | 8.5 ± 0.2b,d | 101 | 80 | 14, P3 |
| Tmc2−/− | Base | 8.6 ± 0.2 | 102 | 37 | 5, P2–P3 |
| Tmc2+/− | Base | 8.1 ± 0.2 | 96 | 14 | 4, P2–P3 |
| Tmc1−/− | Base | 5.0 ± 0.1d | 60 | 26 | 5, P2–P3 |
| Mice | Location | I channel | G channel | n traces | n cells, age |
| pA | pS | ||||
| Wild type | Apex | 5.2 ± 0.1a,b | 62 | 50 | 5, P4–P5 |
| Tmc1+/− | Apex | 5.3 ± 0.1 | 63 | 41 | 4, P4 |
| Tmc1−/− | Apex | 4.1 ± 0.1a | 49 | 93 | 6, P4–P5 |
| Tmc2+/− | Apex | 5.5 ± 0.3 | 65 | 13 | 4, P4 |
| Tmc2−/− | Apex | 5.2 ± 0.2 | 62 | 14 | 4, P4 |
| Tmc1−/−Tmc2−/− | Apex | 5.5 ± 0.1 | 65 | 56 | 4, P5–P6 |
| Tmc1−/−Tmc2−/− | Apex | 2.1 ± 0.03c | 25 | 8 | 3, P6 |
| Wild type | Base | 8.5 ± 0.2b,d | 101 | 80 | 14, P3 |
| Tmc2−/− | Base | 8.6 ± 0.2 | 102 | 37 | 5, P2–P3 |
| Tmc2+/− | Base | 8.1 ± 0.2 | 96 | 14 | 4, P2–P3 |
| Tmc1−/− | Base | 5.0 ± 0.1d | 60 | 26 | 5, P2–P3 |
Location in cochlea at low frequency apex or high frequency base. I channel, single-channel currents measured at a holding potential of −84 mV from amplitude histograms, mean ± SEM; G channel, single-channel conductance; n, number of traces analyzed and cells characterized; P, postnatal age.
Pairs of values were significantly different, P < 0.02.
Pairs of values were significantly different, P < 0.02.
MT channels of similar size were also occasionally seen in wild type and heterozygotes.
Pairs of values were significantly different, P < 0.02.