Parameters of inactivation
| Condition | −β4 Peptide | +β4 Peptide | P-value (−β4 vs. +β4) | ||||||
| V1/2 | k | SS (%) | V1/2 | k | SS (%) | V1/2 | k | SS (%) | |
| mV | mV | mV | mV | ||||||
| WT − ATX (n = 6, 5) | −63.2 ± 0.8 | 5.6 ± 0.1 | 4.4 ± 0.3 | −63.0 ± 1.1 | 5.7 ± 0.3 | 2.9 ± 0.7 | 0.9 | 0.8 | 0.1 |
| WT + ATX (n = 6, 5) | −65.8 ± 1.8 | 8.4 ± 0.3 | 3.9 ± 0.4 | −65.5 ± 2.2 | 8.0 ± 0.3 | 3.5 ± 0.7 | 0.9 | 0.4 | 0.6 |
| CW − ATX (n = 5, 6) | −51.6 ± 2.1 | 14.5 ± 0.8 | 27.1 ± 2.4 | −53.2 ± 1.5 | 13.6 ± 0.5 | 31.4 ± 1.3 | 0.4 | 0.2 | 0.2 |
| CW + ATX (n = 5, 6) | −48.9 ± 1.2 | 7.3 ± 0.7 | 60.6 ± 1.2 | −43.5 ± 1.6 | 10.5 ± 1.1 | 46.7 ± 1.7 | <0.05 | <0.05 | <0.001 |
| Condition | −β4 Peptide | +β4 Peptide | P-value (−β4 vs. +β4) | ||||||
| V1/2 | k | SS (%) | V1/2 | k | SS (%) | V1/2 | k | SS (%) | |
| mV | mV | mV | mV | ||||||
| WT − ATX (n = 6, 5) | −63.2 ± 0.8 | 5.6 ± 0.1 | 4.4 ± 0.3 | −63.0 ± 1.1 | 5.7 ± 0.3 | 2.9 ± 0.7 | 0.9 | 0.8 | 0.1 |
| WT + ATX (n = 6, 5) | −65.8 ± 1.8 | 8.4 ± 0.3 | 3.9 ± 0.4 | −65.5 ± 2.2 | 8.0 ± 0.3 | 3.5 ± 0.7 | 0.9 | 0.4 | 0.6 |
| CW − ATX (n = 5, 6) | −51.6 ± 2.1 | 14.5 ± 0.8 | 27.1 ± 2.4 | −53.2 ± 1.5 | 13.6 ± 0.5 | 31.4 ± 1.3 | 0.4 | 0.2 | 0.2 |
| CW + ATX (n = 5, 6) | −48.9 ± 1.2 | 7.3 ± 0.7 | 60.6 ± 1.2 | −43.5 ± 1.6 | 10.5 ± 1.1 | 46.7 ± 1.7 | <0.05 | <0.05 | <0.001 |