Model parameters
| Channel domain | Transition | Forward rate | Reverse rate | Reverse rate |
| a | a | b | ||
| DI | A↔I1 | 1.74E-04 | 2.99E-04 | 5.17E+02 |
| I1↔I2 | 1.55E-05 | 1.55E-05 | 4.34E+01 | |
| I2↔I3 | 1.12E-06 | 9.57E-03 | 2.04E+01 | |
| DII | A↔I1 | 1.42E-04 | 1.78E-04 | 3.14E+02 |
| I1↔I2 | 9.30E-06 | 9.10E-06 | 2.23E+01 | |
| I2↔I3 | 9.31E-04 | 2.48E-04 | 1.08E+02 | |
| DIII | A↔I1 | 1.78E-04 | 3.34E-04 | not req. |
| I1↔I2 | 5.35E-05 | 3.08E-05 | not req. | |
| I2↔I3 | 1.81E-07 | 3.64E-03 | not req. | |
| DIV | A↔I1 | 2.31E-04 | 5.04E-04 | not req. |
| I1↔I2 | 4.29E-04 | 6.38E-03 | not req. | |
| I2↔I3 | 6.52E-04 | 3.57E-05 | not req. |
| Channel domain | Transition | Forward rate | Reverse rate | Reverse rate |
| a | a | b | ||
| DI | A↔I1 | 1.74E-04 | 2.99E-04 | 5.17E+02 |
| I1↔I2 | 1.55E-05 | 1.55E-05 | 4.34E+01 | |
| I2↔I3 | 1.12E-06 | 9.57E-03 | 2.04E+01 | |
| DII | A↔I1 | 1.42E-04 | 1.78E-04 | 3.14E+02 |
| I1↔I2 | 9.30E-06 | 9.10E-06 | 2.23E+01 | |
| I2↔I3 | 9.31E-04 | 2.48E-04 | 1.08E+02 | |
| DIII | A↔I1 | 1.78E-04 | 3.34E-04 | not req. |
| I1↔I2 | 5.35E-05 | 3.08E-05 | not req. | |
| I2↔I3 | 1.81E-07 | 3.64E-03 | not req. | |
| DIV | A↔I1 | 2.31E-04 | 5.04E-04 | not req. |
| I1↔I2 | 4.29E-04 | 6.38E-03 | not req. | |
| I2↔I3 | 6.52E-04 | 3.57E-05 | not req. |
The discrete-state Markov models used to reproduce experimental data shown in Fig. 8 are parameterized with standard rate transitions: a*exp(−Vm/b). The second parameter, b, which confers voltage dependence to the rate, is only required for DI and DII sensor immobilization. Parameters for the forward and reverse rate transitions between states A and I1, states I1 and I2, and states I2 and I3 for each of the voltage-sensor domains.