Cl− and Na+ permeabilities obtained from GHK fits to instantaneous current-voltage relationships of 15 HEK293 cells
| Cell type | NMDG-Cl in bath | NaCl in bath | PNa/PCl | PCl−NMDG-Cl/PCl−NaCl | ||||
| PCl | ±SD | PCl | ±SD | PNa | ±SD | |||
| 10−14 cm3/s/pF | 10−14 cm3/s/pF | 10−14 cm3/s/pF | 10−14 cm3/s/pF | 10−14 cm3/s/pF | 10−14 cm3/s/pF | |||
| WT | 30.4 | 1.9 | 29.6 | 1.2 | 7.1 | 0.6 | 0.24 | 1.03 |
| WT | 12.9 | 0.6 | 31.7 | 1.0 | 9.7 | 0.5 | 0.31 | 0.41 |
| I342A | 26.8 | 0.8 | 55.6 | 2.0 | 14.7 | 1.7 | 0.26 | 0.48 |
| I342A | 19.8 | 0.8 | 93.8 | 4.2 | 13.3 | 3.6 | 0.14 | 0.21 |
| I342A | 138.5 | 15.0 | 230.2 | 1.6 | 77.9 | 1.4 | 0.34 | 0.60 |
| I342A | 87.2 | 6.9 | 127.6 | 2.4 | 67.7 | 1.9 | 0.53 | 0.68 |
| K616E | 204.1 | 16.0 | 176.8 | 12.7 | 45.8 | 10.6 | 0.26 | 1.15 |
| K616E | 45.7 | 4.7 | 137.7 | 7.7 | 30.6 | 6.4 | 0.22 | 0.33 |
| K616E | 12.8 | 1.0 | 23.4 | 2.5 | 12.7 | 2.1 | 0.54 | 0.55 |
| R592E | 10.6 | 3.4 | 12.7 | 2.3 | 9.7 | 2.0 | 0.76 | 0.83 |
| R592E | 42.4 | 1.3 | 72.7 | 3.5 | 11.2 | 3.0 | 0.15 | 0.58 |
| R636E | 16.2 | 1.7 | 27.3 | 1.8 | 3.1 | 1.5 | 0.11 | 0.59 |
| R636E | 90.0 | 2.4 | 130.4 | 1.2 | 69.5 | 1.0 | 0.53 | 0.69 |
| R636E | 16.9 | 1.5 | 22.9 | 1.7 | 8.0 | 1.4 | 0.35 | 0.74 |
| R636E | 150.0 | 8.5 | 232.0 | 4.6 | 79.9 | 3.8 | 0.34 | 0.65 |
| Cell type | NMDG-Cl in bath | NaCl in bath | PNa/PCl | PCl−NMDG-Cl/PCl−NaCl | ||||
| PCl | ±SD | PCl | ±SD | PNa | ±SD | |||
| 10−14 cm3/s/pF | 10−14 cm3/s/pF | 10−14 cm3/s/pF | 10−14 cm3/s/pF | 10−14 cm3/s/pF | 10−14 cm3/s/pF | |||
| WT | 30.4 | 1.9 | 29.6 | 1.2 | 7.1 | 0.6 | 0.24 | 1.03 |
| WT | 12.9 | 0.6 | 31.7 | 1.0 | 9.7 | 0.5 | 0.31 | 0.41 |
| I342A | 26.8 | 0.8 | 55.6 | 2.0 | 14.7 | 1.7 | 0.26 | 0.48 |
| I342A | 19.8 | 0.8 | 93.8 | 4.2 | 13.3 | 3.6 | 0.14 | 0.21 |
| I342A | 138.5 | 15.0 | 230.2 | 1.6 | 77.9 | 1.4 | 0.34 | 0.60 |
| I342A | 87.2 | 6.9 | 127.6 | 2.4 | 67.7 | 1.9 | 0.53 | 0.68 |
| K616E | 204.1 | 16.0 | 176.8 | 12.7 | 45.8 | 10.6 | 0.26 | 1.15 |
| K616E | 45.7 | 4.7 | 137.7 | 7.7 | 30.6 | 6.4 | 0.22 | 0.33 |
| K616E | 12.8 | 1.0 | 23.4 | 2.5 | 12.7 | 2.1 | 0.54 | 0.55 |
| R592E | 10.6 | 3.4 | 12.7 | 2.3 | 9.7 | 2.0 | 0.76 | 0.83 |
| R592E | 42.4 | 1.3 | 72.7 | 3.5 | 11.2 | 3.0 | 0.15 | 0.58 |
| R636E | 16.2 | 1.7 | 27.3 | 1.8 | 3.1 | 1.5 | 0.11 | 0.59 |
| R636E | 90.0 | 2.4 | 130.4 | 1.2 | 69.5 | 1.0 | 0.53 | 0.69 |
| R636E | 16.9 | 1.5 | 22.9 | 1.7 | 8.0 | 1.4 | 0.35 | 0.74 |
| R636E | 150.0 | 8.5 | 232.0 | 4.6 | 79.9 | 3.8 | 0.34 | 0.65 |
As explained in Eq. 4 (compare with Fig. 7, A–C). The error of each estimate is indicated by the SD of the fit given by the Origin fitting routine (OriginLab).