Model parameters
| Channel domain | Transition | Forward rate | Reverse rate |
| DI L689I | A↔I1 | 1.11E-04 | 4.45E-04 |
| I1↔I2 | 3.97E-05 | 2.24E-05 | |
| I2↔I3 | 3.33E-04 | 9.48E-01 | |
| DII L689I | A↔I1 | 4.91E-05 | 3.56E-04 |
| I1↔I2 | 4.79E-05 | 3.03E-05 | |
| I2↔I3 | 6.19E-09 | 4.91E-02 | |
| DIII L689I | A↔I1 | 2.18E-04 | 4.63E-04 |
| I1↔I2 | 3.82E-05 | 2.38E-05 | |
| I2↔I3 | 2.97E-04 | 3.55E-03 | |
| DIV L689I | A↔I1 | 2.13E-04 | 3.99E-04 |
| I1↔I2 | 1.83E-05 | 2.27E-05 | |
| I2↔I3 | 4.88E-04 | 9.91E-01 |
| Channel domain | Transition | Forward rate | Reverse rate |
| DI L689I | A↔I1 | 1.11E-04 | 4.45E-04 |
| I1↔I2 | 3.97E-05 | 2.24E-05 | |
| I2↔I3 | 3.33E-04 | 9.48E-01 | |
| DII L689I | A↔I1 | 4.91E-05 | 3.56E-04 |
| I1↔I2 | 4.79E-05 | 3.03E-05 | |
| I2↔I3 | 6.19E-09 | 4.91E-02 | |
| DIII L689I | A↔I1 | 2.18E-04 | 4.63E-04 |
| I1↔I2 | 3.82E-05 | 2.38E-05 | |
| I2↔I3 | 2.97E-04 | 3.55E-03 | |
| DIV L689I | A↔I1 | 2.13E-04 | 3.99E-04 |
| I1↔I2 | 1.83E-05 | 2.27E-05 | |
| I2↔I3 | 4.88E-04 | 9.91E-01 |
The discrete-state Markov models used in Fig. 8 in our companion paper (Silva and Goldstein, 2013) are parameterized for the forward and reverse rate transitions between states A and I1, states I1 and I2, and states I2 and I3 for the L689I mutation in each of the voltage-sensor domains.