Table 2. Steady-state inactivation... | Rockefeller University Press

Table 2.

Steady-state inactivation properties for hERG channels with N-terminal region deletions

Construct	V_1/2	k	n
	mV
hERG	−68.69 ± 2.24	19.51 ± 0.50	9
hERG ΔN	−59.60 ± 0.73^a	25.72 ± 0.32^b	8
hERG ΔN + N1–135	−74.15 ± 1.67	19.51 ± 0.34	10
hERG Δeag	−60.97 ± 1.65^a	24.74 ± 0.56^b	9
hERG Δeag + N1–135	−69.71 ± 1.70	20.35 ± 0.37	9
hERG ΔN + N1–354	−68.68 ± 2.35	20.49 ± 0.64	10

Construct	V_1/2	k	n
	mV
hERG	−68.69 ± 2.24	19.51 ± 0.50	9
hERG ΔN	−59.60 ± 0.73^a	25.72 ± 0.32^b	8
hERG ΔN + N1–135	−74.15 ± 1.67	19.51 ± 0.34	10
hERG Δeag	−60.97 ± 1.65^a	24.74 ± 0.56^b	9
hERG Δeag + N1–135	−69.71 ± 1.70	20.35 ± 0.37	9
hERG ΔN + N1–354	−68.68 ± 2.35	20.49 ± 0.64	10

Boltzmann fit values for V_1/2 and slope (k). Values shown are the mean ± SEM; n indicates the number of cells.

P < 0.05 versus HERG WT (ANOVA).

P < 0.01 versus HERG WT (ANOVA).