Table 1. Steady-state activation... | Rockefeller University Press

Table 1.

Steady-state activation properties for hERG channels with N-terminal region deletions

Construct	V_1/2	k	n
	mV
hERG	−27.87 ± 0.54	8.82 ± 0.12	11
hERG ΔN	−14.18 ± 1.31^a	9.77 ± 0.53^b	11
hERG ΔN + N1–135	−18.74 ± 0.64^a	7.31 ± 0.18^a	10
hERG Δeag	−27.19 ± 0.69	8.00 ± 0.25	10
hERG Δeag + N1–135	−31.88 ± 0.66^a	8.19 ± 0.21	9
hERG ΔN + N1–354	−20.14 ± 0.87^a	6.47 ± 0.25^a	10

Construct	V_1/2	k	n
	mV
hERG	−27.87 ± 0.54	8.82 ± 0.12	11
hERG ΔN	−14.18 ± 1.31^a	9.77 ± 0.53^b	11
hERG ΔN + N1–135	−18.74 ± 0.64^a	7.31 ± 0.18^a	10
hERG Δeag	−27.19 ± 0.69	8.00 ± 0.25	10
hERG Δeag + N1–135	−31.88 ± 0.66^a	8.19 ± 0.21	9
hERG ΔN + N1–354	−20.14 ± 0.87^a	6.47 ± 0.25^a	10

Boltzmann fit values for V_1/2 and slope (k). Values shown are the mean ± SEM; n indicates the number of cells.

P < 0.01 versus HERG WT (ANOVA).

P < 0.05 versus HERG WT (ANOVA).