Table 1. Effects of hydrophobic and... | Rockefeller University Press

Table 1.

Effects of hydrophobic and hydrophilic drugs on NaChBac activation and inactivation

	Effects on activation of NaChBac						Effects on inactivation of NaChBac
	Ranolazine (200 μM)		Lidocaine (1 mM)		Benzocaine (1 mM)		Ranolazine (200 μM)		Lidocaine (1 mM)		Benzocaine (1 mM)
	V_1/2	dx	V_1/2	dx	V_1/2	dx	V_1/2	dx	V_1/2	dx	V_1/2	dx
	mV	mV	mV	mV	mV	mV	mV	mV	mV	mV	mV	mV
Control	−19.8 ± 1.4^a	11.1 ± 0.6^a	−26.5 ± 2.8^a	10.4 ± 0.4	−17.9 ± 2.1	9.8 ± 0.2	−50.8 ± 0.6^a	6.2 ± 1.0	−52.0 ± 1.6^a	5.9 ± 0.5	−44.7 ± 0.8^a	7.0 ± 0.2
Drug	−32.8 ± 2.1^a	6.2 ± 0.6^a	−30.5 ± 2.6^a	10.9 ± 0.8	−21.1 ± 5.9	10.0 ± 1.5	−57.9 ± 0.4^a	6.8 ± 0.6	−62.1 ± 1.1^a	5.8 ± 0.4	−58.9 ± 0.8^a	6.9 ± 0.4

	Effects on activation of NaChBac						Effects on inactivation of NaChBac
	Ranolazine (200 μM)		Lidocaine (1 mM)		Benzocaine (1 mM)		Ranolazine (200 μM)		Lidocaine (1 mM)		Benzocaine (1 mM)
	V_1/2	dx	V_1/2	dx	V_1/2	dx	V_1/2	dx	V_1/2	dx	V_1/2	dx
	mV	mV	mV	mV	mV	mV	mV	mV	mV	mV	mV	mV
Control	−19.8 ± 1.4^a	11.1 ± 0.6^a	−26.5 ± 2.8^a	10.4 ± 0.4	−17.9 ± 2.1	9.8 ± 0.2	−50.8 ± 0.6^a	6.2 ± 1.0	−52.0 ± 1.6^a	5.9 ± 0.5	−44.7 ± 0.8^a	7.0 ± 0.2
Drug	−32.8 ± 2.1^a	6.2 ± 0.6^a	−30.5 ± 2.6^a	10.9 ± 0.8	−21.1 ± 5.9	10.0 ± 1.5	−57.9 ± 0.4^a	6.8 ± 0.6	−62.1 ± 1.1^a	5.8 ± 0.4	−58.9 ± 0.8^a	6.9 ± 0.4

Mean ± SEM is given.

Statistical significance was set at P < 0.05.