Table 1.

Time constants and relative areas for exponential fits of dwell-time distributions

Channel Activity  Closed  Open 
  τ Area (%)  τ Area (%) 
  ms   ms  
Sub-activating Po < 0.1 (0.25–1 µM) CI 1.55 ± 0.93 16.08 ± 4.67 OUL 0.19 ± 0.04 42.50 ± 7.82 
 CR 29.21 ± 13.37 70.65 ± 8.13 O1 0.72 ± 0.26 49.00 ± 0.82 
 CNR 51.23 ± 25.60 15.15 ± 6.71 O2 10.4 ± 10.4 13.33 ± 13.03 
Activating Po 0.1–0.6 (1–5 µM) CF 0.92 ± 0.40 13.74 ± 5.41 O1 0.40 ± 0.06 36.04 ± 7.30 
 CR 8.71 ± 1.82 45.34 ± 6.82 O2 2.27 ± 0.33 43.73 ± 0.33 
 CNR 35.81 ± 7.97 37.56 ± 9.84 O3 9.69 ± 1.72 11.80 ± 1.81 
Low saturating Po >0.65 (2–10 µM) CF 0.41 ± 0.03 50.4 ± 5.97 O1 1.02 ± 0.28 15.12 ± 6.87 
 CR 0.94 ± 0.27 47.11 ± 6.17 O2 1.53 ± 0.61 28.70 ± 6.15 
 CNR 30.27 ± 16.09 1.73 ± 0.55 O3 5.67 ± 1.09 38.91 ± 3.32 
    O4 28.09 ± 11.56 9.91 ± 4.07 
High saturation Po >0.8 (100–200 µM) CF 0.36 ± 0.03 54.21 ± 3.96 O1 1.53 ± 0.36 17.68 ± 4.87 
 CR 0.83 ± 0.15 41.90 ± 3.82 O2 2.08 ± 0.50 33.44 ± 3.76 
 CNR 12.23 ± 3.80 1.02 ± 0.15 O3 10.93 ± 1.19 40.39 ± 5.94 
    O4 64.14 ± 33.92 6.08 ± 3.53 
Channel Activity  Closed  Open 
  τ Area (%)  τ Area (%) 
  ms   ms  
Sub-activating Po < 0.1 (0.25–1 µM) CI 1.55 ± 0.93 16.08 ± 4.67 OUL 0.19 ± 0.04 42.50 ± 7.82 
 CR 29.21 ± 13.37 70.65 ± 8.13 O1 0.72 ± 0.26 49.00 ± 0.82 
 CNR 51.23 ± 25.60 15.15 ± 6.71 O2 10.4 ± 10.4 13.33 ± 13.03 
Activating Po 0.1–0.6 (1–5 µM) CF 0.92 ± 0.40 13.74 ± 5.41 O1 0.40 ± 0.06 36.04 ± 7.30 
 CR 8.71 ± 1.82 45.34 ± 6.82 O2 2.27 ± 0.33 43.73 ± 0.33 
 CNR 35.81 ± 7.97 37.56 ± 9.84 O3 9.69 ± 1.72 11.80 ± 1.81 
Low saturating Po >0.65 (2–10 µM) CF 0.41 ± 0.03 50.4 ± 5.97 O1 1.02 ± 0.28 15.12 ± 6.87 
 CR 0.94 ± 0.27 47.11 ± 6.17 O2 1.53 ± 0.61 28.70 ± 6.15 
 CNR 30.27 ± 16.09 1.73 ± 0.55 O3 5.67 ± 1.09 38.91 ± 3.32 
    O4 28.09 ± 11.56 9.91 ± 4.07 
High saturation Po >0.8 (100–200 µM) CF 0.36 ± 0.03 54.21 ± 3.96 O1 1.53 ± 0.36 17.68 ± 4.87 
 CR 0.83 ± 0.15 41.90 ± 3.82 O2 2.08 ± 0.50 33.44 ± 3.76 
 CNR 12.23 ± 3.80 1.02 ± 0.15 O3 10.93 ± 1.19 40.39 ± 5.94 
    O4 64.14 ± 33.92 6.08 ± 3.53 
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