Gating properties of simulated, recombinant, and native A-type Kv channels
| Parameter | V1/2,act | kact | V1/2,inact | kinact | τinact,SP | τinact,DP | VSP/DPa |
| mV | mV | mV | mV | ms | ms | mV | |
| Simulated OSI | 20 | 20.6 | −28.5 | 7.5 | 87.4 | 90.2 | 0 |
| Recombinant Kv3.4 | 28.5 ± 2 (n = 11) | 19.5 ± 0.9 (n = 11) | −36.8 ± 5.3 (n = 5) | 9.9 ± 2.9 (n = 5) | 144 ± 24 (n = 11) | 148 (n = 9) | 0 |
| Native Kv3.4 | 28.4 ± 6 (n = 5) | 25.3 ± 1.2 (n = 5) | −29 ± 2.5 (n = 8) | 8 ± 1.8 (n = 8) | 42.2 ± 5.7 (n = 10) | 33.6 (n = 4) | −10 |
| Simulated CSI | −30 | 27.45 | −108.74 | 4.04 | 11.05 | 10.4 | −20 |
| Recombinant Kv4.2 + DPP6-S + KChIP-1 | −7.3 ± 5.1 (n = 9) | 32.7 ± 1.7 (n = 9) | −89.3 ± 3.6 (n = 5) | 7 ± 0.8 (n = 5) | 18.7 ± 1.3 (n = 9) | 20 (n = 9) | −45 |
| Native Kv4.2 + DPP6-S + KChIP-1 | −8.5 ± 9.6 (n = 5) | 31 ± 3 (n = 5) | −77.5 ± 0.9 (n = 5) | 11.8 ± 0.8 (n = 5) | 30 ± 5.5 (n = 5) | 28.08 (n = 5) | −45 |
| Recombinant Kv4.2 + DPP6-S | −28.2 ± 3.7 (n = 6) | 27.2 ± 1.4 (n = 6) | −87.5 ± 4.4 (n = 5) | 4.9 ± 0.5 (n = 5) | 31.9 ± 4.3 (n = 6) | 34.9 (n = 6) | −65 |
| Recombinant Kv4.2 + DPP10a + KChIP-1 | 9.4 ± 5.2 (n = 7) | 40.4 ± 5.1 (n = 7) | −71.1 ± 3.3 (n = 7) | 5.6 ± 0.7 (n = 7) | 50.9 ± 8.6 (n = 7) | 51 (n = 7) | −35 |
| Parameter | V1/2,act | kact | V1/2,inact | kinact | τinact,SP | τinact,DP | VSP/DPa |
| mV | mV | mV | mV | ms | ms | mV | |
| Simulated OSI | 20 | 20.6 | −28.5 | 7.5 | 87.4 | 90.2 | 0 |
| Recombinant Kv3.4 | 28.5 ± 2 (n = 11) | 19.5 ± 0.9 (n = 11) | −36.8 ± 5.3 (n = 5) | 9.9 ± 2.9 (n = 5) | 144 ± 24 (n = 11) | 148 (n = 9) | 0 |
| Native Kv3.4 | 28.4 ± 6 (n = 5) | 25.3 ± 1.2 (n = 5) | −29 ± 2.5 (n = 8) | 8 ± 1.8 (n = 8) | 42.2 ± 5.7 (n = 10) | 33.6 (n = 4) | −10 |
| Simulated CSI | −30 | 27.45 | −108.74 | 4.04 | 11.05 | 10.4 | −20 |
| Recombinant Kv4.2 + DPP6-S + KChIP-1 | −7.3 ± 5.1 (n = 9) | 32.7 ± 1.7 (n = 9) | −89.3 ± 3.6 (n = 5) | 7 ± 0.8 (n = 5) | 18.7 ± 1.3 (n = 9) | 20 (n = 9) | −45 |
| Native Kv4.2 + DPP6-S + KChIP-1 | −8.5 ± 9.6 (n = 5) | 31 ± 3 (n = 5) | −77.5 ± 0.9 (n = 5) | 11.8 ± 0.8 (n = 5) | 30 ± 5.5 (n = 5) | 28.08 (n = 5) | −45 |
| Recombinant Kv4.2 + DPP6-S | −28.2 ± 3.7 (n = 6) | 27.2 ± 1.4 (n = 6) | −87.5 ± 4.4 (n = 5) | 4.9 ± 0.5 (n = 5) | 31.9 ± 4.3 (n = 6) | 34.9 (n = 6) | −65 |
| Recombinant Kv4.2 + DPP10a + KChIP-1 | 9.4 ± 5.2 (n = 7) | 40.4 ± 5.1 (n = 7) | −71.1 ± 3.3 (n = 7) | 5.6 ± 0.7 (n = 7) | 50.9 ± 8.6 (n = 7) | 51 (n = 7) | −35 |
The voltage at which the single-pulse (SP) and double-pulse (DP) inactivation time constants were measured.