Table 5.

Literature survey of H2O2 emission and electron flow diversion to ROS under FET in isolated mitochondria from different organs and species

Mitochondria source Species H2O2 emission O2 consumption flux diverted to H2O2(State 4–State 3) Reference 
  State 4 State 3   
  nmol/min/mg protein nmol/min/mg protein %  
Heart Rat 0.02 ND 0.4–ND Hansford et al., 1997  
  ndet ND  St-Pierre et al., 2002  
  0.105 0.08 0.3–0.04 This study 
 Pigeon 0.3–0.6 ND 2–ND Chance et al., 1979  
  ndet ND  St-Pierre et al., 2002  
 Guinea pig 0.075 0.047 0.6–0.016 Aon et al., 2010a  
  0.095 0.062 0.2–0.04 This study 
 Mouse 0.107 0.082 1–0.17 This study 
Liver Rat 0.19 0.08 1-2–ND Boveris et al., 1972  
  0.25 ND 1.82–ND Hoffman and Brookes, 2009  
Skeletal muscle Rat <0.2 ND ≤0.15–ND St-Pierre et al., 2002  
Mitochondria source Species H2O2 emission O2 consumption flux diverted to H2O2(State 4–State 3) Reference 
  State 4 State 3   
  nmol/min/mg protein nmol/min/mg protein %  
Heart Rat 0.02 ND 0.4–ND Hansford et al., 1997  
  ndet ND  St-Pierre et al., 2002  
  0.105 0.08 0.3–0.04 This study 
 Pigeon 0.3–0.6 ND 2–ND Chance et al., 1979  
  ndet ND  St-Pierre et al., 2002  
 Guinea pig 0.075 0.047 0.6–0.016 Aon et al., 2010a  
  0.095 0.062 0.2–0.04 This study 
 Mouse 0.107 0.082 1–0.17 This study 
Liver Rat 0.19 0.08 1-2–ND Boveris et al., 1972  
  0.25 ND 1.82–ND Hoffman and Brookes, 2009  
Skeletal muscle Rat <0.2 ND ≤0.15–ND St-Pierre et al., 2002  

In all sources, FET is under G/M or Pyr/M (4–6 mM each). The only exception is St-Pierre et al. (2002), in which the data reported in the table were obtained with palmitoyl carnitine. ndet, non-detected.

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