Voltage-dependent activation of HCN channels
| Cell type, channel, recording configuration | Activation midpoint | ΔV1/2 | |
| Control | cAMP | ||
| mV | mV | mV | |
| CHO, HCN4, whole cell | −106.3 ± 2.7 (9) | −106.6 ± 3.8 (7)a | −0.3 |
| CHO, HCN2, whole cell | −107.7 ± 3.4 (9) | −91.8 ± 2.7 (10)b | +15.9 |
| HEK, HCN4, whole cell | −121.6 ± 5.3 (8)c | −104.3 ± 1.6 (7)b | +17.3 |
| HEK, HCN4-R669Q, whole cell | −123.5 ± 1.2 (7) | −120.1 ± 2.3 (11)a | +3.4 |
| CHO, HCN4, patches | −120.2 ± 3.7 (8) | −118.7 ± 2.8 (8)a | +1.5 ± 1.8 (8) |
| HEK, HCN4, patches | −137.2 ± 2.2 (6)c | −126.1 ± 2.8 (6)b | + 11.1 ± 1.0 (6) |
| CHO, HCN2, patches | −118.2 ± 2.9 (5) | −101.1 ± 2.7 (5)b | +17.1 ± 0.4 (5) |
| CHO, HCN4-2Tail, whole cell | −118.9 ± 2.5 (4) | −105.4 ± 3.0 (5)b | +13.5 |
| CHO, HCN2-4Tail, whole cell | −110.2 ± 2.9 (6) | −78.9 ± 4.3 (4)b | +31.3 |
| CHO, HCN4-Δ719, whole cell | −122.9 ± 2.2 (7)c | −106.7 ± 2.9 (8)b | +16.2 |
| CHO, HCN4-Δ1012, whole cell | −109.2 ± 1.5 (7) | −106.0 ± 1.5 (7)a | +3.2 |
| Cell type, channel, recording configuration | Activation midpoint | ΔV1/2 | |
| Control | cAMP | ||
| mV | mV | mV | |
| CHO, HCN4, whole cell | −106.3 ± 2.7 (9) | −106.6 ± 3.8 (7)a | −0.3 |
| CHO, HCN2, whole cell | −107.7 ± 3.4 (9) | −91.8 ± 2.7 (10)b | +15.9 |
| HEK, HCN4, whole cell | −121.6 ± 5.3 (8)c | −104.3 ± 1.6 (7)b | +17.3 |
| HEK, HCN4-R669Q, whole cell | −123.5 ± 1.2 (7) | −120.1 ± 2.3 (11)a | +3.4 |
| CHO, HCN4, patches | −120.2 ± 3.7 (8) | −118.7 ± 2.8 (8)a | +1.5 ± 1.8 (8) |
| HEK, HCN4, patches | −137.2 ± 2.2 (6)c | −126.1 ± 2.8 (6)b | + 11.1 ± 1.0 (6) |
| CHO, HCN2, patches | −118.2 ± 2.9 (5) | −101.1 ± 2.7 (5)b | +17.1 ± 0.4 (5) |
| CHO, HCN4-2Tail, whole cell | −118.9 ± 2.5 (4) | −105.4 ± 3.0 (5)b | +13.5 |
| CHO, HCN2-4Tail, whole cell | −110.2 ± 2.9 (6) | −78.9 ± 4.3 (4)b | +31.3 |
| CHO, HCN4-Δ719, whole cell | −122.9 ± 2.2 (7)c | −106.7 ± 2.9 (8)b | +16.2 |
| CHO, HCN4-Δ1012, whole cell | −109.2 ± 1.5 (7) | −106.0 ± 1.5 (7)a | +3.2 |