Table 1.

Known phosphorylation sites on UniProt among ETC and TCA proteins in the mouse and human heart

Protein name Species UniProt accession Phosphorylation site(s) 
ATP synthase subunit e Mouse Q06185 Y32 
ATP synthase subunit γ Mouse Q91VR2 S146 
ATP synthase subunit α Mouse Q03265 S76 
ATP synthase subunit β Mouse P56480 S529 
Cytochrome b-c1 complex subunit 1 Human P31930 T381 
Cytochrome b-c1 complex subunit 2 Human P22695 T86 
Cytochrome b-c1 complex subunit 6 Human P07919 S61 
Cytochrome b-c1 complex subunit 6 Mouse P99028 T61 
Fumarate hydratase Human P07954 Y491 
Isocitrate dehydrogenase subunit γ Mouse P70404 T363 
Malate dehydrogenase Human P40926 Y56 
NADH-ubiquinone oxidoreductase 18-kD subunit Human O43181 T32, S34 
NADH-ubiquinone oxidoreductase B22 subunit Human Q9Y6M9 S85 
NADH-ubiquinone oxidoreductase PDSW subunit Human O96000 Y56, Y143 
NADH-ubiquinone oxidoreductase subunit 2 Human P03891 T258 
NADH-ubiquinone oxidoreductase subunit B14.5a Human O95182 S63 
Succinate dehydrogenase flavoprotein subunit Mouse Q8K2B3 T252 
Succinyl-CoA synthetase β-A chain Mouse Q9Z2I9 S279 
Succinyl-CoA synthetase β-A chain Human Q9P2R7 Y84 
Protein name Species UniProt accession Phosphorylation site(s) 
ATP synthase subunit e Mouse Q06185 Y32 
ATP synthase subunit γ Mouse Q91VR2 S146 
ATP synthase subunit α Mouse Q03265 S76 
ATP synthase subunit β Mouse P56480 S529 
Cytochrome b-c1 complex subunit 1 Human P31930 T381 
Cytochrome b-c1 complex subunit 2 Human P22695 T86 
Cytochrome b-c1 complex subunit 6 Human P07919 S61 
Cytochrome b-c1 complex subunit 6 Mouse P99028 T61 
Fumarate hydratase Human P07954 Y491 
Isocitrate dehydrogenase subunit γ Mouse P70404 T363 
Malate dehydrogenase Human P40926 Y56 
NADH-ubiquinone oxidoreductase 18-kD subunit Human O43181 T32, S34 
NADH-ubiquinone oxidoreductase B22 subunit Human Q9Y6M9 S85 
NADH-ubiquinone oxidoreductase PDSW subunit Human O96000 Y56, Y143 
NADH-ubiquinone oxidoreductase subunit 2 Human P03891 T258 
NADH-ubiquinone oxidoreductase subunit B14.5a Human O95182 S63 
Succinate dehydrogenase flavoprotein subunit Mouse Q8K2B3 T252 
Succinyl-CoA synthetase β-A chain Mouse Q9Z2I9 S279 
Succinyl-CoA synthetase β-A chain Human Q9P2R7 Y84 

Proteins from ETC complexes and the TCA cycle were experimentally determined from mouse and human heart mitochondria. The PTM information of the protein was retrieved from UniProt. The referenced phosphorylation sites were identified from their respective species but may have originated from different tissues other than the heart (e.g. mouse liver, human HeLa cells). Tissue-specific PTM distribution is a matter of intense investigation.

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