Table 1.
FDA-approved and phase III CARTs containing a 4-1BB costimulatory domain
NameCompanyTargetIndicationEfficacy in phase I/IIFDA status
Tisagenlecleucel Novartis Anti-CD19/FMC63 DLBCL, ALL DLBCL: 49% OS at 12 mo Approved 
    ALL: 76% OS at 12 mo  
Lisocabtagene maraleucel BMS (formerly Cellgene) Anti-CD19/FMC63 ALL 83% CR at 6 mo Phase III (NCT03575351) 
JNJ-68284528 Janssen Two BCMA-targeting single-domain antibodies MM 90% PF at 9 mo Phase III (NCT04181827) 
Idecabtagene vicleucel BMS (formerly Cellgene) BCMA MM 31.3% CR at 2 yr Phase III (NCT03651128) 
NameCompanyTargetIndicationEfficacy in phase I/IIFDA status
Tisagenlecleucel Novartis Anti-CD19/FMC63 DLBCL, ALL DLBCL: 49% OS at 12 mo Approved 
    ALL: 76% OS at 12 mo  
Lisocabtagene maraleucel BMS (formerly Cellgene) Anti-CD19/FMC63 ALL 83% CR at 6 mo Phase III (NCT03575351) 
JNJ-68284528 Janssen Two BCMA-targeting single-domain antibodies MM 90% PF at 9 mo Phase III (NCT04181827) 
Idecabtagene vicleucel BMS (formerly Cellgene) BCMA MM 31.3% CR at 2 yr Phase III (NCT03651128) 

BCMA, B cell maturation antigen; DLBCL, diffuse large B cell lymphoma; ALL, acute lymphocytic leukemia; OS, overall survival; CR, complete response; PF, progression free.

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