Table I. Properties of mechanically... | Rockefeller University Press

Table I.

Properties of mechanically activated currents in cultured sensory neurons and HEK293 cells expressing Piezo1 or Piezo2

Cell type	Ionic selectivity	Stimuli	Activation tau	Inactivation tau	Adaptation mechanism	Block
		µm	ms	ms
Rat DRG RA^a^b^c^d^e^f	Nonselective cation	2–12^a	ND	3	Voltage-dep., Ca²⁺-indep.	Ca²⁺, Gd³⁺, NMB1, ruthenium red, FM1-43, cytochalasin B
Rat DRG IA^d^e	Nonselective cation	2–12	ND	21	ND	NMB1
Rat DRG SA^a^b^c^d^e^f	Nonselective cation	2–12	ND	296 (τ₁)1,140 (τ₂)	Voltage-dep., Ca²⁺-indep.	Gd³⁺, ruthenium red, cytochalasin B, Ca²⁺, FM1-43
Mouse DRG RA^g^h	Sodium^g	0.75–1 (neurite) 4–6 (soma)	0.8–1.0	1.05–1.92	ND	Gd³⁺, NMDG
Mouse DRG RA^g^h	Nonselective cation^h	16	3	47–57	ND	Ruthenium red
Mouse DRG IA^g	ND	0.75–1 (neurite) 4–6 (soma)	0.5–0.7	17–26	ND	Gd³⁺
Mouse DRG SA^gⁱ	Nonselective cation	0.75–1 (neurite) 4–6 (soma)	0.4–1.3	>230	ND	Gd³⁺, ruthenium red, HC030031ⁱ
HEK293 Piezo1^j	Nonselective cation^j	3	ND	17	ND	Ruthenium red Gd³⁺, Ca²⁺
HEK293 Piezo2^j	Nonselective cation^j	ND	ND	7	ND	Ruthenium red Gd³⁺, NMDG

Cell type	Ionic selectivity	Stimuli	Activation tau	Inactivation tau	Adaptation mechanism	Block
		µm	ms	ms
Rat DRG RA^a^b^c^d^e^f	Nonselective cation	2–12^a	ND	3	Voltage-dep., Ca²⁺-indep.	Ca²⁺, Gd³⁺, NMB1, ruthenium red, FM1-43, cytochalasin B
Rat DRG IA^d^e	Nonselective cation	2–12	ND	21	ND	NMB1
Rat DRG SA^a^b^c^d^e^f	Nonselective cation	2–12	ND	296 (τ₁)1,140 (τ₂)	Voltage-dep., Ca²⁺-indep.	Gd³⁺, ruthenium red, cytochalasin B, Ca²⁺, FM1-43
Mouse DRG RA^g^h	Sodium^g	0.75–1 (neurite) 4–6 (soma)	0.8–1.0	1.05–1.92	ND	Gd³⁺, NMDG
Mouse DRG RA^g^h	Nonselective cation^h	16	3	47–57	ND	Ruthenium red
Mouse DRG IA^g	ND	0.75–1 (neurite) 4–6 (soma)	0.5–0.7	17–26	ND	Gd³⁺
Mouse DRG SA^gⁱ	Nonselective cation	0.75–1 (neurite) 4–6 (soma)	0.4–1.3	>230	ND	Gd³⁺, ruthenium red, HC030031ⁱ
HEK293 Piezo1^j	Nonselective cation^j	3	ND	17	ND	Ruthenium red Gd³⁺, Ca²⁺
HEK293 Piezo2^j	Nonselective cation^j	ND	ND	7	ND	Ruthenium red Gd³⁺, NMDG

McCarter et al. (1999).

Drew et al. (2002).

Drew and Wood (2007).

Drew et al. (2007).

Hao and Delmas (2010).

Rugiero et al. (2010).

Hu and Lewin (2006).

Drew et al. (2004).

Vilceanu and Stucky (2010).

Coste et al. (2010).