Table I.

Rate constant and charge parameters of Kv channel gating models

Model Transitions α0 [s−1] zα β0 [s−1] zβ c 
Zagotta et al. 1994 (Shaker channel) R1–R2 1,120 0.25 373 1.6 1 
 R2–A 2,800 0.32 21.2 1.1 1 
Schoppa and Sigworth 1994 (Shaker channel) S0–S1 1,650 0.47 450 0.52 1.3 
 S1–S2 4,900 0.08 960 0.52 1 
 S2–S3 7,920 0.08 1,560 0.52 1 
Piper et al. 2003 (hERG1 channel) S0–S1 1,000 0.2 1,500 0.04 1 
 S1–S2 150 0.15 280 0.05 1.5 
Standard model (hERG1 channel) fast (e.g., S0–S1) 296 0.43 2,683 0.076 1 
 slow (e.g., S4–S8) 73 0.21 1.9 0.56 1 
Cd2+ model (hERG1 channel) fast (e.g., S0–S1) 563 0.27 2,329 0.23 1 
 slow (e.g., S4–S8) 20.9 0.30 5.7 0.68 1 

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