Changes in the sensitivity of RYR2 to be opened by [Ca2+]i
| A—Increase in RYR2 sensitivity | B—Decrease in RYR2 sensitivity |
| Increased [Ca2+]SR | Decreased [Ca2+]SR |
| (Lukyanenko et al., 1996; Györke and Györke, 1998; Györke et al., 2002) | (Lukyanenko et al., 1996; Györke and Györke, 1998; Györke et al., 2002) |
| RYR2 phosphorylation at PKA or CaMKII sites | Calstabin2 (FKBP 12.6) binding |
| (Valdivia et al., 1995; Li et al., 1998; Marx et al., 2000) | (Marx et al., 2000; Wehrens et al., 2003) |
| Caffeine | Tetracaine |
| (Rousseau and Meissner, 1989; O’Neill and Eisner, 1990; Venetucci et al., 2007) | (Xu et al., 1993; Overend et al., 1997) |
| RYR2 oxidation (ROS) | Anti-oxidation |
| (Hidalgo et al., 2002; Terentyev et al., 2008) | (Hidalgo et al., 2002; Terentyev et al., 2008) |
| RYR2 CPVT mutations | |
| (Marks et al., 2002; Wehrens et al., 2003) | |
| Calsequestrin mutations | |
| (Postma et al., 2002; Eldar et al., 2003; di Barletta et al., 2006; Knollmann et al., 2006) | |
| Triadin | |
| (Valdivia et al., 1995; Li et al., 1998; Marx et al., 2000; Györke and Terentyev, 2008; Chopra et al., 2009) | |
| RYR2 nitrosylation | |
| (Xu et al., 1998; Sun et al., 2008; Bellinger et al., 2009) |
| A—Increase in RYR2 sensitivity | B—Decrease in RYR2 sensitivity |
| Increased [Ca2+]SR | Decreased [Ca2+]SR |
| (Lukyanenko et al., 1996; Györke and Györke, 1998; Györke et al., 2002) | (Lukyanenko et al., 1996; Györke and Györke, 1998; Györke et al., 2002) |
| RYR2 phosphorylation at PKA or CaMKII sites | Calstabin2 (FKBP 12.6) binding |
| (Valdivia et al., 1995; Li et al., 1998; Marx et al., 2000) | (Marx et al., 2000; Wehrens et al., 2003) |
| Caffeine | Tetracaine |
| (Rousseau and Meissner, 1989; O’Neill and Eisner, 1990; Venetucci et al., 2007) | (Xu et al., 1993; Overend et al., 1997) |
| RYR2 oxidation (ROS) | Anti-oxidation |
| (Hidalgo et al., 2002; Terentyev et al., 2008) | (Hidalgo et al., 2002; Terentyev et al., 2008) |
| RYR2 CPVT mutations | |
| (Marks et al., 2002; Wehrens et al., 2003) | |
| Calsequestrin mutations | |
| (Postma et al., 2002; Eldar et al., 2003; di Barletta et al., 2006; Knollmann et al., 2006) | |
| Triadin | |
| (Valdivia et al., 1995; Li et al., 1998; Marx et al., 2000; Györke and Terentyev, 2008; Chopra et al., 2009) | |
| RYR2 nitrosylation | |
| (Xu et al., 1998; Sun et al., 2008; Bellinger et al., 2009) |