Time constants (τ) and apparent modification rates (R) for current attenuation by MBB and MTSET in wt Panx1 and Panx1 I60C, C426S channels
| Parameter | Channel | 10 µM MBB | 100 µM MBB | 100 µM MTSET | 1 mM MTSET |
| τ (s) | |||||
| wt Panx1 | 28.5 ± 1.5 (4) | ||||
| Panx1 I60C | 129 ± 12.4 (4) | 26.4 ± 4.1 (5) | 164 ± 8 (3) | 60 ± 9.8 (4) | |
| R (M−1s−1) | |||||
| wt Panx1 | 351 | ||||
| Panx1 I60C | 775 | 378 | 61 | 17 | |
| Parameter | Channel | 10 µM MBB | 100 µM MBB | 100 µM MTSET | 1 mM MTSET |
| τ (s) | |||||
| wt Panx1 | 28.5 ± 1.5 (4) | ||||
| Panx1 I60C | 129 ± 12.4 (4) | 26.4 ± 4.1 (5) | 164 ± 8 (3) | 60 ± 9.8 (4) | |
| R (M−1s−1) | |||||
| wt Panx1 | 351 | ||||
| Panx1 I60C | 775 | 378 | 61 | 17 | |
Means ± SE and the number of oocytes analyzed are given. The τ’s for wt Panx1 and I60C were not significantly different. Significant differences (P > 0.05) were found between the means for 10 and 100 µM MBB and between 100 µM and 1 mM MTSET. The means for MBB and MTSET each at 100 µM were also significantly different.