LIGHT in disease and clinical applications
| Disease . | LIGHT function and evidence . |
|---|---|
| COVID-19 | LIGHT expression as a prognostic biomarker in COVID-19 (Arunachalam et al., 2020; Perlin et al., 2020; Tan et al., 2021) |
| IBD | Reduced intestinal inflammation by LIGHT neutralization in a colitis model (Jungbeck et al., 2009) |
| Asthma, IPF, SSc | LIGHT drives fibrosis and tissue remodeling in the lung (Doherty et al., 2011; Herro et al., 2015) |
| Atopic dermatitis, scleroderma | LIGHT induces changes in keratinocytes and promotes epidermal and dermal thickening (Herro et al., 2015, 2018) |
| Metabolic diseases | Elevated LIGHT level in patients with type 2 diabetes (Halvorsen et al., 2016) LIGHT-mediated inflammation implicated in nonalcoholic fatty liver disease (Herrero-Cervera et al., 2019) |
| Postmenopausal osteoporosis | Antagonizing LIGHT could be therapeutically beneficial in patients with postmenopausal osteoporosis (Brunetti et al., 2020) |
| Cancer | LIGHT was found to play a role in antitumor immunity (Holmes et al., 2014) LTβR signaling implicated in tumor metastasis by inducing anti-tumor effector cells (Lu and Browning, 2014) |
| RA | Lymphotoxin/LIGHT axis decreases the IFN signature in patients’ blood cells (Bienkowska et al., 2014) |
| Disease . | LIGHT function and evidence . |
|---|---|
| COVID-19 | LIGHT expression as a prognostic biomarker in COVID-19 (Arunachalam et al., 2020; Perlin et al., 2020; Tan et al., 2021) |
| IBD | Reduced intestinal inflammation by LIGHT neutralization in a colitis model (Jungbeck et al., 2009) |
| Asthma, IPF, SSc | LIGHT drives fibrosis and tissue remodeling in the lung (Doherty et al., 2011; Herro et al., 2015) |
| Atopic dermatitis, scleroderma | LIGHT induces changes in keratinocytes and promotes epidermal and dermal thickening (Herro et al., 2015, 2018) |
| Metabolic diseases | Elevated LIGHT level in patients with type 2 diabetes (Halvorsen et al., 2016) LIGHT-mediated inflammation implicated in nonalcoholic fatty liver disease (Herrero-Cervera et al., 2019) |
| Postmenopausal osteoporosis | Antagonizing LIGHT could be therapeutically beneficial in patients with postmenopausal osteoporosis (Brunetti et al., 2020) |
| Cancer | LIGHT was found to play a role in antitumor immunity (Holmes et al., 2014) LTβR signaling implicated in tumor metastasis by inducing anti-tumor effector cells (Lu and Browning, 2014) |
| RA | Lymphotoxin/LIGHT axis decreases the IFN signature in patients’ blood cells (Bienkowska et al., 2014) |