Table II. Charge movement and... | Rockefeller University Press

Table II.

Charge movement and conductance fit parameters

Genotype/treatment	Q-V			I-V			G/Q
	Q_max	V_Q	k_Q	G_max	V_1/2	k_G	G_max/Q_max
	nC/µF	mV	mV	nS/nF	mV	mV	nS/pC
WT	9.9 ± 1.1	1.8 ± 2.9	8.9 ± 0.6	300 ± 18	24.8 ± 1.2	6.0 ± 0.2	30
	(7)			(25)
WT + Bay K 8644	ND			256 ± 16	15.4 ± 1.7^a	5.6 ± 0.4	ND
				(9)
Het	7.4 ± 1.0	−9.9 ± 2.9^b	10.2 ± 1.3	229 ± 14^c	19.7 ± 1.2^c	5.9 ± 0.2	31
	(7)			(22)
Het + Bay K 8644	ND			254 ± 28	11.7 ± 1.4^a	6.0 ± 0.2	ND
				(6)
Hom	6.4 ± 0.7^b	−13.7 ± 2.3^a	8.8 ± 1.1	208 ± 10^a	17.9 ± 1.1^a	6.0 ± 0.3	32
	(7)			(28)
Hom + Bay K 8644	ND			254 ± 28	11.2 ± 1.3^a	6.4 ± 0.3	ND
				(9)

Genotype/treatment	Q-V			I-V			G/Q
	Q_max	V_Q	k_Q	G_max	V_1/2	k_G	G_max/Q_max
	nC/µF	mV	mV	nS/nF	mV	mV	nS/pC
WT	9.9 ± 1.1	1.8 ± 2.9	8.9 ± 0.6	300 ± 18	24.8 ± 1.2	6.0 ± 0.2	30
	(7)			(25)
WT + Bay K 8644	ND			256 ± 16	15.4 ± 1.7^a	5.6 ± 0.4	ND
				(9)
Het	7.4 ± 1.0	−9.9 ± 2.9^b	10.2 ± 1.3	229 ± 14^c	19.7 ± 1.2^c	5.9 ± 0.2	31
	(7)			(22)
Het + Bay K 8644	ND			254 ± 28	11.7 ± 1.4^a	6.0 ± 0.2	ND
				(6)
Hom	6.4 ± 0.7^b	−13.7 ± 2.3^a	8.8 ± 1.1	208 ± 10^a	17.9 ± 1.1^a	6.0 ± 0.3	32
	(7)			(28)
Hom + Bay K 8644	ND			254 ± 28	11.2 ± 1.3^a	6.4 ± 0.3	ND
				(9)

Average values of parameters obtained by fits of Eqs. 2 and 3 to Q-V and I-V data, respectively (see Materials and methods). Where indicated, myotubes were exposed to 10 µM ±Bay K 8644 for >10 min before experiments. Data are given as mean ± SEM, with the numbers in parentheses indicating the number of myotubes tested. ND, not determined.

Significant differences compared to L-type currents or charge movements recorded from untreated WT myotubes; P < 0.001, t test.

P < 0.05, t test.

P < 0.005, t test.

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