Table I. Steady-state inactivation... | Rockefeller University Press

Table I.

Steady-state inactivation parameters of WT Ca_V1.2 and D1546K Ca_V1.2 EF-hand mutant at different Mg_i concentrations

	WT Ca_V1.2				D1546K
[Mg_i] (mM)	V_1/2 (mV)	k (mV)	I_non-inact^a	n	V_1/2 (mV)	k (mV)	I_non-inact^a	n
0.26	−31.6 ± 0.8	9.6 ± 0.7	0.26 ± 0.04	13	−29.8 ± 0.5	9.2 ± 0.5	0.32 ± 0.04	5
0.8	−31.2 ± 0.7	9.4 ± 0.7	0.15 ± 0.04	9	−31.7 ± 1.0	10.2 ± 1.1	0.28 ± 0.04^b	5
2.4	−36.0 ± 0.2^c	8.7 ± 0.2	0.05 ± 0.02^d	4	−36.9 ± 0.8^c	7.3 ± 0.7	0.22 ± 0.07^b	8
7.2	−47.3 ± 0.2^c	9.0 ± 0.1	0.02 ± 0.01^c	10	−43.4 ± 0.3^c	6.1 ± 0.3	0.05 ± 0.01^c	5

	WT Ca_V1.2				D1546K
[Mg_i] (mM)	V_1/2 (mV)	k (mV)	I_non-inact^a	n	V_1/2 (mV)	k (mV)	I_non-inact^a	n
0.26	−31.6 ± 0.8	9.6 ± 0.7	0.26 ± 0.04	13	−29.8 ± 0.5	9.2 ± 0.5	0.32 ± 0.04	5
0.8	−31.2 ± 0.7	9.4 ± 0.7	0.15 ± 0.04	9	−31.7 ± 1.0	10.2 ± 1.1	0.28 ± 0.04^b	5
2.4	−36.0 ± 0.2^c	8.7 ± 0.2	0.05 ± 0.02^d	4	−36.9 ± 0.8^c	7.3 ± 0.7	0.22 ± 0.07^b	8
7.2	−47.3 ± 0.2^c	9.0 ± 0.1	0.02 ± 0.01^c	10	−43.4 ± 0.3^c	6.1 ± 0.3	0.05 ± 0.01^c	5

Non-inactivating normalized Ca_V1.2 (Na) current after a 4-s depolarization at 20 mV.

Values are significantly different from WT; P < 0.05.

Values are significantly (P < 0.01) different than parameters at 0.26 mM Mg_i.

Values are significantly (P < 0.05) different than parameters at 0.26 mM Mg_i.