Cytoplasmic Membrane Interface Residues Contributing >1 kcal/mole Static Field Energy to the Interaction of K+ along the Pore for Z < 0 Å
| Cytoplasmic membrane interface . | . | . | . | . | . | . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| KirBac1.1 | K57 | S59 | P61 | F63 | R148 | R151 | — | R153 | Q182 | |||||||||
| Kir1.1 | D74 | K76 | R78 | K80 | K181 | R184 | K187 | R188 | K218 | |||||||||
| Kir2.1 | D78 | R80 | R82 | M84 | K182 | K185 | K188 | R189 | K219 | |||||||||
| Kir3.1 | D77 | K79 | R81 | N83 | K183 | Q186 | K189 | R190 | N220 | |||||||||
| Kir6.2 | D65 | K67 | P69 | T71 | K170 | Q173 | R176 | R177 | K207 | |||||||||
| Cytoplasmic membrane interface . | . | . | . | . | . | . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| KirBac1.1 | K57 | S59 | P61 | F63 | R148 | R151 | — | R153 | Q182 | |||||||||
| Kir1.1 | D74 | K76 | R78 | K80 | K181 | R184 | K187 | R188 | K218 | |||||||||
| Kir2.1 | D78 | R80 | R82 | M84 | K182 | K185 | K188 | R189 | K219 | |||||||||
| Kir3.1 | D77 | K79 | R81 | N83 | K183 | Q186 | K189 | R190 | N220 | |||||||||
| Kir6.2 | D65 | K67 | P69 | T71 | K170 | Q173 | R176 | R177 | K207 | |||||||||
Residues are aligned across the five Kir channels to show the variation at each position between strongly contributing residues (bold) and non-electrostatic counterparts (italics). The blue spheres in Fig. 1 A highlight the positions of these nine sites.